Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Cryptosporidium parvum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2S)-2-[(1-naphthyl)amino]-N-[2-(pyridin-4-yl)-1,3-benzoxazol-5-yl]propanamide | competitive versus NAD+ | Cryptosporidium parvum | |
(2S)-2-[(3,4-dichlorophenyl)amino]-N-[2-(pyridin-4-yl)-1,3-benzoxazol-5-yl]propanamide | competitive versus NAD+, displays excellent IMPDH inhibitory activity and moderate stability in mouse liver microsomes | Cryptosporidium parvum | |
2-[(3,4-dichlorophenyl)amino]-N-[2-(pyridin-4-yl)-1,3-benzoxazol-5-yl]propanamide | racemic variant, competitive versus NAD+. Compound displays good antiparasitic activity in a Toxoplasma gondii strain that relies on Cryptosporidium parvum IMPDH, EC50 20 nM. No toxicity is observed against four mammalian cells lines | Cryptosporidium parvum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cryptosporidium parvum | Q8T6T2 | - |
- |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000005 | - |
pH 8.0, 25°C | Cryptosporidium parvum | (2S)-2-[(3,4-dichlorophenyl)amino]-N-[2-(pyridin-4-yl)-1,3-benzoxazol-5-yl]propanamide | |
0.000002 | - |
pH 8.0, 25°C | Cryptosporidium parvum | 2-[(3,4-dichlorophenyl)amino]-N-[2-(pyridin-4-yl)-1,3-benzoxazol-5-yl]propanamide | |
0.000014 | - |
pH 8.0, 25°C | Cryptosporidium parvum | (2S)-2-[(1-naphthyl)amino]-N-[2-(pyridin-4-yl)-1,3-benzoxazol-5-yl]propanamide |