Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
GTP | - |
Mus musculus | |
Mycophenolic acid | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
IMP + NAD+ + H2O | Mus musculus | - |
XMP + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P50096 | - |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA agarose resin column chromatography | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
retina | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
IMP + NAD+ + H2O | - |
Mus musculus | XMP + NADH + H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer or octamer | - |
Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
IMPDH1 | - |
Mus musculus |
inosine monophosphate dehydrogenase-1 | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | defects in inosine monophosphate dehydrogenase-1 lead to insufficient biosyntheses of purine nucleotides and are believed to cause retinitis pigmentosa in eyes | Mus musculus |