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Literature summary for extracted from

  • Dengler, U.; Niefind, K.; Kiess, M.; Schomburg, D.
    Crystal structure of a ternary complex of D-2-hydroxyisocaproate dehydrogenase from Lactobacillus casei, NAD+ and 2-oxoisocaproate at 1.9 A resolution (1997), J. Mol. Biol., 267, 640-660.
    View publication on PubMed


Cloned (Comment) Organism
expression in Escherichia coli Lacticaseibacillus paracasei

Crystallization (Commentary)

Crystallization (Comment) Organism
hexagonal crystals of recombinant D-HicDH in the presence of NAD+ and 2-oxoisocaproate (4-methyl-2-oxopentanoate) are grown with ammonium sulfate as precipitating agent. The structure of the crystals is solved by molecular replacement and refined to a final R-factor of 19.6% for all measured X-ray reflections in the resolution range 1.9 A resolution Lacticaseibacillus paracasei

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2 * 37000, SDS-PAGE Lacticaseibacillus paracasei


Organism UniProt Comment Textmining
Lacticaseibacillus paracasei P17584

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information very low specificity regarding size and chemical constitution of the accepted D-2-hydroxycarboxylates Lacticaseibacillus paracasei ?


Subunits Comment Organism
homodimer 2 * 37000, SDS-PAGE Lacticaseibacillus paracasei


Synonyms Comment Organism
D-2-hydroxyisocaproate dehydrogenase
Lacticaseibacillus paracasei
Lacticaseibacillus paracasei