Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-lactate + ferricytochrome c | Saccharomyces cerevisiae | - |
pyruvate + ferrocytochrome c + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | P00175 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-lactate + ferricytochrome c | - |
Saccharomyces cerevisiae | pyruvate + ferrocytochrome c + H+ | - |
? | |
L-lactate + ferricytochrome c | molecular dynamics studies on active-site models of flavocytochrome b2 in complex with the substrate for analysis of the mechanism of the enzyme-catalyzed L-lactate oxidation reaction, overview. In the calculated enzyme-substrate model complex, the l-lactate alpha-OH hydrogen is hydrogen bonded to the activesite base H373 Ne, whereas the Halpha is directed towards flavin N5, suggesting that the reaction is initiated by a-OH proton abstraction | Saccharomyces cerevisiae | pyruvate + ferrocytochrome c + H+ | - |
? | |
additional information | the role of the flavin mononucleotide-ribityl chain 2'OH group in maintaining the conserved K349 in a geometry favoring flavin reduction, of an active site water molecule belonging to a S371-Wat-D282-H373 hydrogen-bonded chain, which modulates the reactivity of the key catalytic histidine, and of the flavin C4a-C10a locus in facilitating proton transfer from the substrate to the active-site base, favoring the initial step of the lactate dehydrogenation reaction | Saccharomyces cerevisiae | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
homotetramer | enzyme-substrate structure analysis during thr reaction cycle, overview | Saccharomyces cerevisiae |
Synonyms | Comment | Organism |
---|---|---|
Fcb2 | - |
Saccharomyces cerevisiae |
flavocytochrome b2 | - |
Saccharomyces cerevisiae |
L-lactate: cytochrome c oxidoreductase | - |
Saccharomyces cerevisiae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cytochrome c | - |
Saccharomyces cerevisiae |