Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Mycobacterium tuberculosis |
Protein Variants | Comment | Organism |
---|---|---|
C387A | the mutation confers resistance to benzothiazinones | Mycobacterium tuberculosis |
C387G | the mutation confers resistance to benzothiazinones and reduces the overall catalytic efficiency by about 4fold compared to the wild type enzyme | Mycobacterium tuberculosis |
C387N | the mutation confers resistance to benzothiazinones and reduces the overall catalytic efficiency by about 4fold compared to the wild type enzyme | Mycobacterium tuberculosis |
C387S | the mutation confers resistance to benzothiazinones | Mycobacterium tuberculosis |
C387T | the mutation confers resistance to benzothiazinones | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-[4-(cyclohexylmethyl)piperazin-1-yl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one | complete inhibition at 0.04 mM | Mycobacterium tuberculosis | |
3-{[(4-methoxyphenyl)methyl]amino}-6-(trifluoromethyl)quinoxaline-2-carboxylic acid | 97% inhibition at 0.04 mM | Mycobacterium tuberculosis | |
additional information | not inhibited by rifampin | Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
trans,octacis-decaprenylphospho-beta-D-ribofuranose + FAD | Mycobacterium tuberculosis | - |
trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + FADH2 | - |
? | |
trans,octacis-decaprenylphospho-beta-D-ribofuranose + FAD | Mycobacterium tuberculosis H37Rv | - |
trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + FADH2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WJF1 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WJF1 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trans,octacis-decaprenylphospho-beta-D-ribofuranose + FAD | - |
Mycobacterium tuberculosis | trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + FADH2 | - |
? | |
trans,octacis-decaprenylphospho-beta-D-ribofuranose + FAD | - |
Mycobacterium tuberculosis H37Rv | trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + FADH2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
decaprenylphosphoryl-beta-D-ribose oxidase | - |
Mycobacterium tuberculosis |
DprE1 | - |
Mycobacterium tuberculosis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Mycobacterium tuberculosis |