KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | protein-ligand molecular docking and thermodynamics, overview | Gluconobacter oxydans |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | membrane-bound dehydrogenase | Gluconobacter oxydans | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
53580 | - |
- |
Gluconobacter oxydans |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-sorbitol + acceptor | Gluconobacter oxydans | - |
L-sorbose + reduced acceptor | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gluconobacter oxydans | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-sorbitol + acceptor | - |
Gluconobacter oxydans | L-sorbose + reduced acceptor | - |
? | |
additional information | binding mode of D-sorbitol with sorbitol dehydrogenase using QM-polarized ligand docking and molecular dynamics simulations, His302, Met366, and Asp368 actively participate in D-sorbitol binding, H302 directly forms hydrogen bonds with D-sorbitol and the role of His302 is to hold the D-sorbitol, overview | Gluconobacter oxydans | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 53580, about, sequence calculation | Gluconobacter oxydans |
More | structure analysis by QM-polarized ligand docking and molecular dynamics simulations, modelling, overview | Gluconobacter oxydans |
Synonyms | Comment | Organism |
---|---|---|
D-sorbitol dehydrogenase | - |
Gluconobacter oxydans |
SDH | - |
Gluconobacter oxydans |
General Information | Comment | Organism |
---|---|---|
malfunction | mutation of His302 results in the denaturation of protein structure and loss of stability | Gluconobacter oxydans |
metabolism | membrane-bound D-sorbitol dehydrogenase is involved in the biotransformation of D-sorbitol to L-sorbose | Gluconobacter oxydans |
additional information | sequence alignment-based homology modeling using the structure of NAD-bound sorbitol dehydrogenase, EC 1.1.1.14, with UniProt ID Q9KWR5 as template | Gluconobacter oxydans |