Diversity and evolutionary analysis of iron-containing (type-III) alcohol dehydrogenases in eukaryotes
Gaona-Lopez, C.; Julian-Sanchez, A.; Riveros-Rosas, H.; PLoS ONE 11, e0166851 (2016) 
Data extracted from this reference:
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
(S)-3-hydroxybutanoate + 2-oxoglutarate
Heterostelium pallidum
-
acetoacetate + (R)-2-hydroxyglutarate
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
Aphanomyces astaci
-
acetoacetate + (R)-2-hydroxyglutarate
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
Aphanomyces invadans
-
acetoacetate + (R)-2-hydroxyglutarate
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
Saprolegnia parasitica
-
acetoacetate + (R)-2-hydroxyglutarate
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
Saprolegnia diclina
-
acetoacetate + (R)-2-hydroxyglutarate
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
Thecamonas trahens
-
acetoacetate + (R)-2-hydroxyglutarate
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
Dictyostelium purpureum
-
acetoacetate + (R)-2-hydroxyglutarate
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
Acytostelium subglobosum
-
acetoacetate + (R)-2-hydroxyglutarate
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
Acytostelium subglobosum LB1
-
acetoacetate + (R)-2-hydroxyglutarate
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
Aphanomyces astaci APO3
-
acetoacetate + (R)-2-hydroxyglutarate
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
Saprolegnia parasitica CBS223.65
-
acetoacetate + (R)-2-hydroxyglutarate
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
Aphanomyces invadans NJM9701
-
acetoacetate + (R)-2-hydroxyglutarate
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
Saprolegnia diclina VS20
-
acetoacetate + (R)-2-hydroxyglutarate
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
Thecamonas trahens ATCC 50062
-
acetoacetate + (R)-2-hydroxyglutarate
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Acanthamoeba castellanii
L8HAM2
-
-
Acanthamoeba castellanii NEFF
L8HAM2
-
-
Acytostelium subglobosum
-
-
-
Acytostelium subglobosum LB1
-
-
-
Aphanomyces astaci
W4G0G7
-
-
Aphanomyces astaci APO3
W4G0G7
-
-
Aphanomyces invadans
A0A024TMA3
-
-
Aphanomyces invadans NJM9701
A0A024TMA3
-
-
Capsaspora owczarzaki
-
-
-
Capsaspora owczarzaki ATCC 30864
-
-
-
Dictyostelium discoideum
-
-
-
Dictyostelium purpureum
F1A5G4
-
-
Heterostelium pallidum
-
-
-
Phaeodactylum tricornutum
B7FWP2
-
-
Phaeodactylum tricornutum CCAP 1055/1
B7FWP2
-
-
Reticulomyxa filosa
X6NPJ7
-
-
Saprolegnia diclina
T0Q1Z2
-
-
Saprolegnia diclina VS20
T0Q1Z2
-
-
Saprolegnia parasitica
A0A067BRK4
-
-
Saprolegnia parasitica CBS223.65
A0A067BRK4
-
-
Thalassiosira oceanica
K0T042
-
-
Thecamonas trahens
A0A0L0DHP5
-
-
Thecamonas trahens ATCC 50062
A0A0L0DHP5
-
-
Tieghemostelium lacteum
F4PTP3
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
(S)-3-hydroxybutanoate + 2-oxoglutarate
-
741263
Heterostelium pallidum
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
-
741263
Aphanomyces astaci
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
-
741263
Aphanomyces invadans
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
-
741263
Saprolegnia parasitica
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
-
741263
Saprolegnia diclina
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
-
741263
Thecamonas trahens
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
-
741263
Dictyostelium purpureum
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
-
741263
Acytostelium subglobosum
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
-
741263
Acytostelium subglobosum LB1
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
-
741263
Aphanomyces astaci APO3
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
-
741263
Saprolegnia parasitica CBS223.65
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
-
741263
Aphanomyces invadans NJM9701
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
-
741263
Saprolegnia diclina VS20
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
-
741263
Thecamonas trahens ATCC 50062
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
Synonyms
Synonyms
Commentary
Organism
HOT
-
Dictyostelium discoideum
HOT
-
Heterostelium pallidum
HOT
-
Thalassiosira oceanica
HOT
-
Aphanomyces astaci
HOT
-
Aphanomyces invadans
HOT
-
Saprolegnia parasitica
HOT
-
Saprolegnia diclina
HOT
-
Thecamonas trahens
HOT
-
Reticulomyxa filosa
HOT
-
Acanthamoeba castellanii
HOT
-
Tieghemostelium lacteum
HOT
-
Dictyostelium purpureum
HOT
-
Phaeodactylum tricornutum
HOT
-
Capsaspora owczarzaki
HOT
-
Acytostelium subglobosum
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
(S)-3-hydroxybutanoate + 2-oxoglutarate
Heterostelium pallidum
-
acetoacetate + (R)-2-hydroxyglutarate
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
Aphanomyces astaci
-
acetoacetate + (R)-2-hydroxyglutarate
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
Aphanomyces invadans
-
acetoacetate + (R)-2-hydroxyglutarate
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
Saprolegnia parasitica
-
acetoacetate + (R)-2-hydroxyglutarate
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
Saprolegnia diclina
-
acetoacetate + (R)-2-hydroxyglutarate
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
Thecamonas trahens
-
acetoacetate + (R)-2-hydroxyglutarate
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
Dictyostelium purpureum
-
acetoacetate + (R)-2-hydroxyglutarate
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
Acytostelium subglobosum
-
acetoacetate + (R)-2-hydroxyglutarate
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
Acytostelium subglobosum LB1
-
acetoacetate + (R)-2-hydroxyglutarate
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
Aphanomyces astaci APO3
-
acetoacetate + (R)-2-hydroxyglutarate
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
Saprolegnia parasitica CBS223.65
-
acetoacetate + (R)-2-hydroxyglutarate
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
Aphanomyces invadans NJM9701
-
acetoacetate + (R)-2-hydroxyglutarate
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
Saprolegnia diclina VS20
-
acetoacetate + (R)-2-hydroxyglutarate
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
Thecamonas trahens ATCC 50062
-
acetoacetate + (R)-2-hydroxyglutarate
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
(S)-3-hydroxybutanoate + 2-oxoglutarate
-
741263
Heterostelium pallidum
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
-
741263
Aphanomyces astaci
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
-
741263
Aphanomyces invadans
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
-
741263
Saprolegnia parasitica
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
-
741263
Saprolegnia diclina
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
-
741263
Thecamonas trahens
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
-
741263
Dictyostelium purpureum
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
-
741263
Acytostelium subglobosum
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
-
741263
Acytostelium subglobosum LB1
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
-
741263
Aphanomyces astaci APO3
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
-
741263
Saprolegnia parasitica CBS223.65
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
-
741263
Aphanomyces invadans NJM9701
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
-
741263
Saprolegnia diclina VS20
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
-
741263
Thecamonas trahens ATCC 50062
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
Other publictions for EC 1.1.99.24
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
741433
Yang
RNA interference-mediated knoc ...
Bemisia tabaci
Sci. Rep.
7
41201
2017
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
1
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
1
-
1
1
-
-
-
741263
Gaona-Lopez
Diversity and evolutionary ana ...
Dictyostelium discoideum, Heterostelium pallidum, Capsaspora owczarzaki, Acytostelium subglobosum, Aphanomyces invadans, Saprolegnia parasitica, Thecamonas trahens, Phaeodactylum tricornutum, Dictyostelium purpureum, Tieghemostelium lacteum, Thalassiosira oceanica, Acanthamoeba castellanii, Saprolegnia diclina, Aphanomyces astaci, Reticulomyxa filosa, Acytostelium subglobosum LB1, Phaeodactylum tricornutum CCAP 1055/1, Aphanomyces astaci APO3, Saprolegnia parasitica CBS223.65, Aphanomyces invadans NJM9701, Capsaspora owczarzaki ATCC 30864, Saprolegnia diclina VS20, Thecamonas trahens ATCC 50062, Acanthamoeba castellanii NEFF
PLoS ONE
11
e0166851
2016
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14
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49
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14
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15
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14
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14
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697277
Lyon
Enzymes involved in the metabo ...
Homo sapiens
Chem. Biol. Interact.
178
283-287
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
2
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-
-
-
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-
-
664967
Kardon
Identification of the gene enc ...
Homo sapiens, Mus musculus, Rattus norvegicus
FEBS Lett.
580
2347-2350
2006
1
-
1
-
-
-
3
12
1
2
3
4
-
10
-
-
2
-
-
13
1
-
7
1
5
2
-
-
-
3
-
-
3
2
-
2
1
-
1
3
-
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2
6
2
12
1
2
3
4
-
-
-
2
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13
1
-
7
1
2
-
-
-
3
-
-
-
-
-
-
-
-
-
675230
Struys
Kinetic characterization of hu ...
Homo sapiens
J. Inherit. Metab. Dis.
28
921-930
2005
-
-
-
-
-
-
-
-
-
-
-
2
-
6
-
-
-
-
-
3
1
-
3
-
1
1
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-
-
1
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1
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1
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2
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3
1
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
286147
Kaufman
An overview of gamma-hydroxybu ...
Rattus norvegicus
Neurochem. Res.
16
965-974
1991
-
-
-
-
-
-
-
5
-
-
-
-
-
1
-
-
-
-
-
-
2
-
4
-
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5
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2
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
287797
Kaufman
Isolation and characterization ...
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
J. Biol. Chem.
263
16872-16879
1988
-
-
-
-
-
1
1
5
2
-
-
-
-
165
-
-
1
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-
4
1
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1
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1
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1
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1
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5
2
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1
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4
1
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10
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1
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1
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