Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
the crystal structure of melatonin and 2-iodomelatonin in complex with quinone reductase 2 provide a detailed description of the enzyme active site that can now be utilized in the design of new and potent inhibitors of the enzyme, hanging-drop vapour-diffusion method | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-iodomelatonin | - |
Homo sapiens | |
5-hydroxytryptamine | - |
Homo sapiens | |
Melatonin | competitive inhibitor against N-methyldihydronicotinamide, uncompetitive against menadione. Melatonin and its analogues bind to and inhibit QR2 within the active site and not at an allosteric site | Homo sapiens | |
N-acetyl-5-hydroxytryptamine | - |
Homo sapiens | |
resveratrol | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P16083 | recombinant | - |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-methyldihydronicotinamide + menadione | - |
Homo sapiens | N-methylnicotinamide + menadiol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MT3 | - |
Homo sapiens |
QR2 | - |
Homo sapiens |
quinone reductase 2 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
- |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
- |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0072 | - |
Melatonin | pH 8, 25°C, competitive inhibitor against N-methyldihydronicotinamide | Homo sapiens | |
0.092 | - |
Melatonin | pH 8, 25°C, uncompetitive against menadione | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00096 | - |
pH 8, 25°C | Homo sapiens | resveratrol | |
0.0011 | - |
pH 8, 25°C | Homo sapiens | 2-iodomelatonin | |
0.0099 | - |
pH 8, 25°C | Homo sapiens | N-acetyl-5-hydroxytryptamine | |
0.0113 | - |
pH 8, 25°C | Homo sapiens | Melatonin | |
0.0539 | - |
pH 8, 25°C | Homo sapiens | 5-hydroxytryptamine |