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Literature summary for 1.11.1.27 extracted from

  • Lopez Grueso, M.J.; Tarradas Valero, R.M.; Carmona-Hidalgo, B.; Lagal Ruiz, D.J.; Peinado, J.; McDonagh, B.; Requejo Aguilar, R.; Barcena Ruiz, J.A.; Padilla Pena, C.A.
    Peroxiredoxin 6 down-regulation induces metabolic remodeling and cell cycle arrest in HepG2 cells (2019), Antioxidants (Basel), 8, 505 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 glutathione + ROOH Homo sapiens
-
 glutathione disulfide + H2O + ROH
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P30041
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-
hepatoblastoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 glutathione + ROOH
-
 Homo sapiens glutathione disulfide + H2O + ROH
-
 ?

Synonyms

Synonyms Comment Organism
peroxiredoxin 6
-
 Homo sapiens
Prdx6
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction peroxiredoxin 6 down-regulation reduces cell proliferation. Enzyme silencing interferes with apoptotic signaling from CD95 but does not induce apoptosis in HepG2 cells Homo sapiens