Literature summary for 1.11.1.8 extracted from

Williams, D.E.; Le, S.N.; Hoke, D.E.; Chandler, P.G.; Gora, M.; Godlewska, M.; Banga, J.P.; Buckle, A.M.
Structural studies of thyroid peroxidase show the monomer interacting with autoantibodies in thyroid autoimmune disease (2020), Endocrinology, 161, 1-16 .

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Protein Variants

Protein Variants	Comment	Organism
additional information	a TPO construct containing only the ectodomain of TPO and lacking the propeptide is enzymatically active and able to bind the patient-derived TR1.9 autoantibody. The TR1.9 autoantibody preferentially binds the TPO monomer and inhibits the catalytic activity	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
TR1.9 autoantibody	preferentially binds the TPO monomer and inhibits the catalytic activity	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P07202	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
guaiacol + H2O2	-	Homo sapiens	tetraguaiacol + H2O	-	?

Subunits

Subunits	Comment	Organism
dimer	and monomer, 1 * 110000, SDS-PAGE, recombinant His-tagged TPO construct lacking the propeptide and recombinant GCN4 leucine zipper-tagged TPO construct lacking the propeptide	Homo sapiens
monomer	and dimer, 1 * 110000, SDS-PAGE, recombinant His-tagged TPO construct lacking the propeptide and recombinant GCN4 leucine zipper-tagged TPO construct lacking the propeptide	Homo sapiens

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Release 2023.1 (January 2023)