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Literature summary for 1.13.11.20 extracted from

  • Fischer, A.A.; Miller, J.R.; Jodts, R.J.; Ekanayake, D.M.; Lindeman, S.V.; Brunold, T.C.; Fiedler, A.T.
    Spectroscopic and computational comparisons of thiolate-ligated ferric nonheme complexes to cysteine dioxygenase second-sphere effects on substrate (analogue) positioning (2019), Inorg. Chem., 58, 16487-16499 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
synthetic construct
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-
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Synonyms

Synonyms Comment Organism
CDO
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 synthetic construct

General Information

General Information Comment Organism
metabolism mononuclear Co(II) complexes with the general formula [Co2+(TpR2)(CysOEt)] (R = Ph or Me, TpR2 = hydrotris(pyrazol-1-yl)borate substituted with R-groups at the 3- and 5-positions, and CysOEt is the anion of L-cysteine ethyl ester) mimic the active-site structure of substrate-bound CDO and are analogous to functional iron-based CDO models. The complexes possess five-coordinate structures featuring facially-coordinatingTpR2 and S,N-bidentate CysOEt ligands. The air-stability of the Ph-variant replicates the inactivity of cobalt-substituted CDO. The Me-variant reversibly binds O2 at reduced temperatures to yield an orange chromophore. Both are high-spin (S = 3/2) complexes. The orange chromophore is a S = 1/2 species featuring a low-spin Co(III) center bound to an end-on (eta1) superoxo ligand synthetic construct