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Literature summary for 1.13.11.34 extracted from

  • Nandha, B.; Ramareddy, S.A.; Kuntal, H.
    Synthesis of substituted fluorobenzimidazoles as inhibitors of 5-lipoxygenase and soluble epoxide hydrolase for anti-inflammatory activity (2018), Arch. Pharm., 351, e1800030 .
    View publication on PubMed
Search for more literature for 1.13.11.34

Inhibitors

Inhibitors Comment Organism Structure
2-[[5-fluoro-6-(4-fluorophenoxy)-1H-benzimidazol-2-yl]sulfanyl]-2-methylpropanoic acid additionally inhibts soluble epoxide hydrolase. Compound shows potent anti-inflammatory activity and significant inhibition of edema at a dose of 100 mg/kg Glycine max
4-([[5-fluoro-6-(1H-1,2,4-triazol-1-yl)-1H-benzimidazol-2-yl]sulfanyl]methyl)benzoic acid additionally inhibts soluble epoxide hydrolase. Compound shows potent anti-inflammatory activity and significant inhibition of edema at a dose of 100 mg/kg Glycine max
4-([[5-fluoro-6-(4-fluorophenoxy)-1H-benzimidazol-2-yl]sulfanyl]methyl)benzoic acid additionally inhibts soluble epoxide hydrolase. Compound shows potent anti-inflammatory activity and significant inhibition of edema at a dose of 100 mg/kg Glycine max
4-([[6-(4-chlorophenoxy)-5-fluoro-1H-benzimidazol-2-yl]sulfanyl]methyl)benzoic acid additionally inhibts soluble epoxide hydrolase. Compound shows potent anti-inflammatory activity and significant inhibition of edema at a dose of 100 mg/kg Glycine max
4-[([5-fluoro-6-[4-(1H-imidazol-1-yl)phenoxy]-1H-benzimidazol-2-yl]sulfanyl)methyl]benzoic acid additionally inhibts soluble epoxide hydrolase. Compound shows potent anti-inflammatory activity and significant inhibition of edema at a dose of 100 mg/kg Glycine max
nordihydroguaiaretic acid
-
 Glycine max

Organism

Organism UniProt Comment Textmining
Glycine max
-
-
-

Synonyms

Synonyms Comment Organism
5-LOX
-
 Glycine max

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0009
-
 pH 7.0, 25°C Glycine max 4-([[5-fluoro-6-(4-fluorophenoxy)-1H-benzimidazol-2-yl]sulfanyl]methyl)benzoic acid
0.003
-
 pH 7.0, 25°C Glycine max 4-([[6-(4-chlorophenoxy)-5-fluoro-1H-benzimidazol-2-yl]sulfanyl]methyl)benzoic acid
0.005
-
 pH 7.0, 25°C Glycine max 2-[[5-fluoro-6-(4-fluorophenoxy)-1H-benzimidazol-2-yl]sulfanyl]-2-methylpropanoic acid
0.0125
-
 pH 7.0, 25°C Glycine max nordihydroguaiaretic acid
0.03
-
 pH 7.0, 25°C Glycine max 4-[([5-fluoro-6-[4-(1H-imidazol-1-yl)phenoxy]-1H-benzimidazol-2-yl]sulfanyl)methyl]benzoic acid
0.035
-
 pH 7.0, 25°C Glycine max 4-([[5-fluoro-6-(1H-1,2,4-triazol-1-yl)-1H-benzimidazol-2-yl]sulfanyl]methyl)benzoic acid