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Literature summary for 1.13.11.52 extracted from
- Indoleamine 2,3-dioxygenase (1987), Methods Enzymol., 142, 188-195.
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| copper | ratio of copper to heme is less than 0.03 | Oryctolagus cuniculus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-Trp + O2 | Oryctolagus cuniculus | influenza virus infection and tumor transplantation induce the enzyme | L-formylkynurenine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | contains approximately 5% carbohydrate per weight | Oryctolagus cuniculus |
| glycoprotein | 1.2 galactose, 2.6 mannose, 5.2 N-acetylglucosamine and 0.8 sialic acid residues per mol of enzyme | Oryctolagus cuniculus |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Oryctolagus cuniculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| intestine | - |
Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-5-hydroxytryptophan + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
| D-Trp + O2 | - |
Oryctolagus cuniculus | N-formyl-D-kynurenine | - |
? | |
| L-5-hydroxytryptophan + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
| L-Trp + O2 | - |
Oryctolagus cuniculus | L-formylkynurenine | - |
? | |
| L-Trp + O2 | influenza virus infection and tumor transplantation induce the enzyme | Oryctolagus cuniculus | L-formylkynurenine | - |
? | |
| tryptamine + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.65 | - |
L-Trp | 24°C | Oryctolagus cuniculus | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| heme | 0.8 mol of protoheme IX per mol of enzyme | Oryctolagus cuniculus | |
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Release 2023.1 (January 2023)
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