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Literature summary for 1.13.11.52 extracted from

  • Reniers, J.; Meinguet, C.; Moineaux, L.; Masereel, B.; Vincent, S.P.; Frederick, R.; Wouters, J.
    Synthesis and inhibition study of monoamine oxidase, indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase by 3,8-substituted 5H-indeno[1,2-c]pyridazin-5-one derivatives (2011), Eur. J. Med. Chem., 46, 6104-6111.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
3-methyl-8-(4,4,4-trifluorobutoxy)-5H-indeno[1,2-c]pyridazin-5-one 31% inhibition at 0.025 mM Cupriavidus metallidurans
3-methyl-8-[(3-methylbenzyl)oxy]-5H-indeno[1,2-c]pyridazin-5-one 66% inhibition at 0.025 mM Cupriavidus metallidurans
8-(4,4,4-trifluorobutoxy)-3-[3-(trifluoromethyl)phenyl]-5H-indeno[1,2-c]pyridazin-5-one 20% inhibition at 0.025 mM Cupriavidus metallidurans
8-(benzyloxy)-3-[3-(trifluoromethyl)phenyl]-5H-indeno[1,2-c]pyridazin-5-one
-
 Cupriavidus metallidurans
8-methoxy-3-[3-(trifluoromethyl)phenyl]-5H-indeno[1,2-c]pyridazin-5-one 18% inhibition at 0.025 mM Cupriavidus metallidurans
8-[(3-chlorobenzyl)oxy]-3-methyl-5H-indeno[1,2-c]pyridazin-5-one 19% inhibition at 0.025 mM Cupriavidus metallidurans
additional information synthesis and inhibition study of tryptophan 2,3-dioxygenase with 3,8-substituted 5H-indeno[1,2-c]pyridazin-5-one derivatives, overview. No inhibition by 7b Cupriavidus metallidurans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + O2 Cupriavidus metallidurans
-
 N-formyl-L-kynurenine
-
 ?

Organism

Organism UniProt Comment Textmining
Cupriavidus metallidurans
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + O2
-
 Cupriavidus metallidurans N-formyl-L-kynurenine
-
 ?

Synonyms

Synonyms Comment Organism
TDO
-
 Cupriavidus metallidurans