Literature summary for 1.13.11.52 extracted from

Bando, H.; Lee, Y.; Sakaguchi, N.; Pradipta, A.; Ma, J.S.; Tanaka, S.; Cai, Y.; Liu, J.; Shen, J.; Nishikawa, Y.; Sasai, M.; Yamamoto, M.
Inducible nitric oxide synthase is a key host factor for Toxoplasma GRA15-dependent disruption of the gamma interferon-induced antiparasitic human response (2018), mBio, 9, e01738-18 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P14902	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
THP-1 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
IDO1	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	IFN-gamma stimulates the expression of indoleamine 2,3-dioxygenase	up

General Information

General Information	Comment	Organism
metabolism	infection of THP-1 cells with GRA15-intact Toxoplasma gondii produces IL-1beta in a manner dependent on NLRP3 and caspase-1. This leads to an indirect reduction in IDO1 proteins, thereby supporting parasite growth in human cells	Homo sapiens
physiological function	IFN-gamma stimulates the expression of indoleamine 2,3-dioxygenase to degrade tryptophan, an essential nutritional amino acid for the intracellular growth of Toxoplasma gondii in human cells	Homo sapiens

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Release 2023.1 (January 2023)