Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,6,6-trimethyl-10,11-dioxo-2-(thiophen-3-yl)-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl propanoate | 0.02 mM, 29.3% inhibition | Homo sapiens | |
1,6,6-trimethyl-10,11-dioxo-2-phenyl-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl propanoate | 0.02 mM, 21.5% inhibition | Homo sapiens | |
1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl 1,3-thiazole-2-carboxylate | - |
Homo sapiens | |
1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl acetate | - |
Homo sapiens | |
1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl benzoate | 0.02 mM, 54.5% inhibition | Homo sapiens | |
1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl cyclohexanecarboxylate | 0.02 mM, 48.0% inhibition | Homo sapiens | |
1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl cyclopropanecarboxylate | - |
Homo sapiens | |
1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl furan-3-carboxylate | - |
Homo sapiens | |
1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl hydroxyacetate | - |
Homo sapiens | |
1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl propanoate | - |
Homo sapiens | |
1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl thiophene-2-carboxylate | 0.02 mM, 60.4% inhibition | Homo sapiens | |
1,6,6-trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione | 0.02 mM, 23.1% inhibition | Homo sapiens | |
1,6,6-trimethyl-6,7-dihydrophenanthro[1,2-b]furan-10,11-dione | 0.02 mM, 61.2% inhibition | Homo sapiens | |
1,6,6-trimethylphenanthro[1,2-b]furan-7,10,11(6H)-trione | - |
Homo sapiens | |
1,6,6-trimethylphenanthro[1,2-b]furan-9,10,11(6H)-trione | 0.02 mM, 52.7% inhibition | Homo sapiens | |
1-(hydroxymethyl)-6,6-dimethylphenanthro[1,2-b]furan-7,10,11(6H)-trione | - |
Homo sapiens | |
1-(hydroxymethyl)-6,6-dimethylphenanthro[1,2-b]furan-9,10,11(6H)-trione | 0.02 mM, 68% inhibition | Homo sapiens | |
7-hydroxy-1,6,6-trimethyl-6,7-dihydrophenanthro[1,2-b]furan-10,11-dione | - |
Homo sapiens | |
9-hydroxy-1,6,6-trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione | - |
Homo sapiens | |
epacadostat | - |
Homo sapiens | |
ethyl 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl (2E)-but-2-enedioate | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P14902 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
IDO-1 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000086 | - |
pH 6.5, 37°C | Homo sapiens | epacadostat | |
0.00037 | - |
37°C, pH 6.5 | Homo sapiens | 1-(hydroxymethyl)-6,6-dimethylphenanthro[1,2-b]furan-7,10,11(6H)-trione | |
0.00084 | - |
37°C, pH 6.5 | Homo sapiens | 1,6,6-trimethylphenanthro[1,2-b]furan-7,10,11(6H)-trione | |
0.00274 | - |
37°C, pH 6.5 | Homo sapiens | 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl hydroxyacetate | |
0.00283 | - |
37°C, pH 6.5 | Homo sapiens | 9-hydroxy-1,6,6-trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione | |
0.0031 | - |
37°C, pH 6.5 | Homo sapiens | 7-hydroxy-1,6,6-trimethyl-6,7-dihydrophenanthro[1,2-b]furan-10,11-dione | |
0.00372 | - |
37°C, pH 6.5 | Homo sapiens | 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl acetate | |
0.0046 | - |
37°C, pH 6.5 | Homo sapiens | 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl furan-3-carboxylate | |
0.00472 | - |
37°C, pH 6.5 | Homo sapiens | 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl propanoate | |
0.00571 | - |
37°C, pH 6.5 | Homo sapiens | 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl 1,3-thiazole-2-carboxylate | |
0.00705 | - |
37°C, pH 6.5 | Homo sapiens | 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl cyclopropanecarboxylate | |
0.00747 | - |
37°C, pH 6.5 | Homo sapiens | ethyl 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl (2E)-but-2-enedioate | |
0.0215 | - |
37°C, pH 6.5 | Homo sapiens | 1,6,6-trimethyl-10,11-dioxo-2-phenyl-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl propanoate | |
0.0293 | - |
37°C, pH 6.5 | Homo sapiens | 1,6,6-trimethyl-10,11-dioxo-2-(thiophen-3-yl)-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl propanoate |
General Information | Comment | Organism |
---|---|---|
drug target | as an immunosuppressive enzyme, indoleamine 2,3-dioxygenase 1 is considered a promising target for oncology immunotherapy | Homo sapiens |