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Literature summary for 1.14.11.1 extracted from

  • Lesniak, R.K.; Rydzik, A.M.; Kamps, J.J.A.G.; Kahn, A.; Claridge, T.D.W.; Schofield, C.J.
    19F NMR studies on gamma-butyrobetaine hydroxylase provide mechanistic insights and suggest a dual inhibition mode (2019), Chem. Commun. (Camb.), 55, 14717-14720 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.1

Inhibitors

Inhibitors Comment Organism Structure
4-([(2E)-3-carboxyprop-2-enoyl](hydroxy)amino)-N,N,N-trimethylbutan-1-aminium i.e. RL190B Homo sapiens
Isoquinoline
-
 Homo sapiens
N-(3-hydroxypyridine-2-carbonyl)-S-[(pyridin-2-yl)methyl]-L-cysteine i.e AR692B Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ dependent on Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-trimethylammoniobutanoate + 2-oxoglutarate + O2 Homo sapiens
-
 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O75936
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-trimethylammoniobutanoate + 2-oxoglutarate + O2
-
 Homo sapiens 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2
-
 ?

Subunits

Subunits Comment Organism
dimer
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
BBOX
-
 Homo sapiens
gamma-butyrobetaine hydroxylase
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0002
-
 pH and temperature not specified in the publication Homo sapiens N-(3-hydroxypyridine-2-carbonyl)-S-[(pyridin-2-yl)methyl]-L-cysteine
0.0009
-
 pH and temperature not specified in the publication Homo sapiens Isoquinoline
0.015
-
 pH and temperature not specified in the publication Homo sapiens 4-([(2E)-3-carboxyprop-2-enoyl](hydroxy)amino)-N,N,N-trimethylbutan-1-aminium

General Information

General Information Comment Organism
metabolism the enzyme catalyzes the final step in the biosynthesis of L-carnitine in humans Homo sapiens