Literature summary for 1.14.11.2 extracted from

Shi, R.; Gao, S.; Zhang, J.; Xu, J.; Graham, L.; Yang, X.; Li, C.
Collagen prolyl 4-hydroxylases modify tumor progression (2021), Acta Biochim. Biophys. Sin. (Shanghai), 53, 805-814 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
procollagen L-proline + 2-oxoglutarate + O2	Homo sapiens	-	procollagen trans-4-hydroxy-L-proline + succinate + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O15460	O15460: prolyl 4-hydroxylase subunit alpha-2 (P4HA2)	-
Homo sapiens	P13674	P13674: prolyl 4-hydroxylase subunit alpha-1 (P4HA1)	-
Homo sapiens	Q7Z4N8	Q7Z4N8: prolyl 4-hydroxylase subunit alpha-3 (P4HA3)	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
procollagen L-proline + 2-oxoglutarate + O2	-	Homo sapiens	procollagen trans-4-hydroxy-L-proline + succinate + CO2	-	?

Subunits

Subunits	Comment	Organism
tetramer	vertebrate C-P4H is an alpha2beta2 tetramer with three isoenzymes differing in the catalytic alpha-subunits, which are encoded by P4HA1, P4HA2, and P4HA3 genes. The beta-subunit is encoded by a single gene P4HB	Homo sapiens

Synonyms

Synonyms	Comment	Organism
C-P4H	-	Homo sapiens
collagen prolyl 4-hydroxylase	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	the expressions of P4HAs and P4HB are regulated by multiple cellular factors, including cytokines, transcription factors, and microRNAs. P4HAs and P4HB are highly expressed in many tumors. P4HB expression is significantly upregulated in a variety of cancers, including HCC, RCC, glioma, GC, and melanoma, and its upregulation correlates with cancer metastasis and invasion	up

General Information

General Information	Comment	Organism
drug target	C-P4H is a potential diagnostic marker and therapeutic target for cancer patients	Homo sapiens
physiological function	the enzyme is essential for the stability. As a key enzyme in collagen synthesis, C-P4H can modulate cancer cell behavior via regulating collagen synthesisy of the collagen triple helix. P4HAs and P4HB are highly expressed in many tumors and participate in cancer progression	Homo sapiens

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Release 2023.1 (January 2023)