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Literature summary for 1.14.11.2 extracted from

  • Murthy, A.V.; Sulu, R.; Koski, M.K.; Tu, H.; Anantharajan, J.; Sah-Teli, S.K.; Myllyharju, J.; Wierenga, R.K.
    Structural enzymology binding studies of the peptide-substrate-binding domain of human collagen prolyl 4-hydroxylase (type-II) High affinity peptides have a PxGP sequence motif (2018), Protein Sci., 27, 1692-1703 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.2

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structures of the PSB domain of the human C-P4H isoform II (PSB-II) complexed with and without various short proline-rich peptides are described Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
procollagen L-proline + 2-oxoglutarate + O2 Homo sapiens
-
 procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O15460 prolyl 4-hydroxylase subunit alpha-2 (PSB-II)
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
procollagen L-proline + 2-oxoglutarate + O2
-
 Homo sapiens procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
procollagen L-proline + 2-oxoglutarate + O2 PxGP (where x is not a proline) is the common motif of proline-rich peptide sequences that bind with high affinity to the enzyme (PSB-II) Homo sapiens procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?

Subunits

Subunits Comment Organism
tetramer alpha2beta2 Homo sapiens

Synonyms

Synonyms Comment Organism
C-P4H
-
 Homo sapiens
collagen prolyl 4-hydroxylase (type-II)
-
 Homo sapiens
PSB-II
-
 Homo sapiens