BRENDA - Enzyme Database show
show all sequences of 1.14.11.27

The histone H3K36 demethylase Rph1/KDM4 regulates the expression of the photoreactivation gene PHR1

Liang, C.Y.; Hsu, P.H.; Chou, D.F.; Pan, C.Y.; Wang, L.C.; Huang, W.C.; Tsai, M.D.; Lo, W.S.; Nucleic Acids Res. 39, 4151-4165 (2011)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
gene rph1
Saccharomyces cerevisiae
Engineering
Amino acid exchange
Commentary
Organism
H235A
catalytically deficient mutant
Saccharomyces cerevisiae
General Stability
General Stability
Organism
the JmjN domain is important in maintaining protein stability and the repressive effect of Rph1
Saccharomyces cerevisiae
Inhibitors
Inhibitors
Commentary
Organism
Structure
additional information
expression of GTT1, UGX2, CTT1, and HSP26 is highly induced by H2O2 treatment and causes the dissociation of Rph1 from the promoters of these genes
Saccharomyces cerevisiae
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
chromatin
Rph1 is associated with a specific chromatin locus. Release of Rph1 from chromatin also required the phosphorylation at S652
Saccharomyces cerevisiae
785
-
nucleus
-
Saccharomyces cerevisiae
5634
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
histone H3-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2
Saccharomyces cerevisiae
-
histone H3-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
-
-
?
histone H3-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2
Saccharomyces cerevisiae BY4742
-
histone H3-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
-
-
?
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2
Saccharomyces cerevisiae
-
histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
-
-
?
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2
Saccharomyces cerevisiae BY4742
-
histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
-
-
?
additional information
Saccharomyces cerevisiae
Rph1 is a histone demethylase specific to tri-methylated-H3K36. Rph1 binds to the URS of PHR1 through ZF domains and modulates chromatin modifications in specific regions of the PHR1 promoter
?
-
-
-
additional information
Saccharomyces cerevisiae BY4742
Rph1 is a histone demethylase specific to tri-methylated-H3K36. Rph1 binds to the URS of PHR1 through ZF domains and modulates chromatin modifications in specific regions of the PHR1 promoter
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Saccharomyces cerevisiae
-
; gene rph1
-
Saccharomyces cerevisiae BY4742
-
gene rph1
-
Posttranslational Modification
Posttranslational Modification
Commentary
Organism
phosphoprotein
Rph1 is phosphorylated under oxidative stress, which leads to Rph1 dissociation and transcriptional activation. Rad53 may be the key kinase essential for Rph1 phosphorylation on oxidative stress with H2O2 treatment; the crucial checkpoint protein Rad53 acts as an upstream regulator of Rph1 and dominates the phosphorylation of Rph1 that is required for efficient PHR1 expression and the dissociation of Rph1. Release of Rph1 from chromatin also required the phosphorylation at S652
Saccharomyces cerevisiae
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
histone H3-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2
-
726071
Saccharomyces cerevisiae
histone H3-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
-
-
-
?
histone H3-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2
-
726071
Saccharomyces cerevisiae BY4742
histone H3-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
-
-
-
?
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2
-
726071
Saccharomyces cerevisiae
histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
-
-
-
?
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2
-
726071
Saccharomyces cerevisiae BY4742
histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
-
-
-
?
additional information
Rph1 is a histone demethylase specific to tri-methylated-H3K36. Rph1 binds to the URS of PHR1 through ZF domains and modulates chromatin modifications in specific regions of the PHR1 promoter
726071
Saccharomyces cerevisiae
?
-
-
-
-
additional information
Rph1 is a histone demethylase specific to tri-methylated-H3K36. Rph1 binds to the URS of PHR1 through ZF domains and modulates chromatin modifications in specific regions of the PHR1 promoter
726071
Saccharomyces cerevisiae BY4742
?
-
-
-
-
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
30
-
assay at
Saccharomyces cerevisiae
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
-
assay at
Saccharomyces cerevisiae
Cloned(Commentary) (protein specific)
Commentary
Organism
gene rph1
Saccharomyces cerevisiae
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
H235A
catalytically deficient mutant
Saccharomyces cerevisiae
General Stability (protein specific)
General Stability
Organism
the JmjN domain is important in maintaining protein stability and the repressive effect of Rph1
Saccharomyces cerevisiae
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
additional information
expression of GTT1, UGX2, CTT1, and HSP26 is highly induced by H2O2 treatment and causes the dissociation of Rph1 from the promoters of these genes
Saccharomyces cerevisiae
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
chromatin
Rph1 is associated with a specific chromatin locus. Release of Rph1 from chromatin also required the phosphorylation at S652
Saccharomyces cerevisiae
785
-
nucleus
-
Saccharomyces cerevisiae
5634
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
histone H3-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2
Saccharomyces cerevisiae
-
histone H3-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
-
-
?
histone H3-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2
Saccharomyces cerevisiae BY4742
-
histone H3-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
-
-
?
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2
Saccharomyces cerevisiae
-
histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
-
-
?
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2
Saccharomyces cerevisiae BY4742
-
histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
-
-
?
additional information
Saccharomyces cerevisiae
Rph1 is a histone demethylase specific to tri-methylated-H3K36. Rph1 binds to the URS of PHR1 through ZF domains and modulates chromatin modifications in specific regions of the PHR1 promoter
?
-
-
-
additional information
Saccharomyces cerevisiae BY4742
Rph1 is a histone demethylase specific to tri-methylated-H3K36. Rph1 binds to the URS of PHR1 through ZF domains and modulates chromatin modifications in specific regions of the PHR1 promoter
?
-
-
-
Posttranslational Modification (protein specific)
Posttranslational Modification
Commentary
Organism
phosphoprotein
Rph1 is phosphorylated under oxidative stress, which leads to Rph1 dissociation and transcriptional activation. Rad53 may be the key kinase essential for Rph1 phosphorylation on oxidative stress with H2O2 treatment; the crucial checkpoint protein Rad53 acts as an upstream regulator of Rph1 and dominates the phosphorylation of Rph1 that is required for efficient PHR1 expression and the dissociation of Rph1. Release of Rph1 from chromatin also required the phosphorylation at S652
Saccharomyces cerevisiae
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
histone H3-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2
-
726071
Saccharomyces cerevisiae
histone H3-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
-
-
-
?
histone H3-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2
-
726071
Saccharomyces cerevisiae BY4742
histone H3-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
-
-
-
?
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2
-
726071
Saccharomyces cerevisiae
histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
-
-
-
?
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2
-
726071
Saccharomyces cerevisiae BY4742
histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
-
-
-
?
additional information
Rph1 is a histone demethylase specific to tri-methylated-H3K36. Rph1 binds to the URS of PHR1 through ZF domains and modulates chromatin modifications in specific regions of the PHR1 promoter
726071
Saccharomyces cerevisiae
?
-
-
-
-
additional information
Rph1 is a histone demethylase specific to tri-methylated-H3K36. Rph1 binds to the URS of PHR1 through ZF domains and modulates chromatin modifications in specific regions of the PHR1 promoter
726071
Saccharomyces cerevisiae BY4742
?
-
-
-
-
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
30
-
assay at
Saccharomyces cerevisiae
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
-
assay at
Saccharomyces cerevisiae
Expression
Organism
Commentary
Expression
Saccharomyces cerevisiae
checkpoint kinase Rad53 negatively modulates Rph1 protein level; the crucial checkpoint protein Rad53 acts as an upstream regulator of Rph1 and dominates the phosphorylation of Rph1 that is required for efficient PHR1 expression and the dissociation of Rph1
down
Saccharomyces cerevisiae
Rph1 is phosphorylated under oxidative stress, which leads to Rph1 dissociation and transcriptional activation. Rad53 may be the key kinase essential for Rph1 phosphorylation on oxidative stress with H2O2 treatment
up
General Information
General Information
Commentary
Organism
evolution
Rph1 is a histone demethylase containing a Jumonji C (JmjC) domain and belongs to the C2H2 zinc-finger protein family
Saccharomyces cerevisiae
malfunction
histone H3K36A mutant shows increased UV sensitivity. Deletion of rph1 leads to approximately 2fold enhancement of PHR1 under normal conditions. Overexpression of Rph1 reduces the expression of PHR1 and increased UV sensitivity. The catalytically deficient mutant H235A of Rph1 diminishes the repressive transcriptional effect on PHR1 expression, which indicates that histone demethylase activity contributes to transcriptional repression; more than 75% of Rph1-regulated genes show increased expression in the rph1-deletion mutant
Saccharomyces cerevisiae
additional information
Rph1 is a labile protein, and Rad53 negatively modulates Rph1 protein level. The JmjN domain is important in maintaining protein stability and the repressive effect of Rph1. Binding motif 5'-CCCCTWA-3', which resembles the stress re­sponse element, is overrepresented in the promoters of Rph1-repressed genes. JmjN and ZF domains of Rph1 are required for its function. Rph1 binds to gene promoters and is dissociated with DNA damage
Saccharomyces cerevisiae
physiological function
histone H3K36 demethylase Rph1/KDM4 regulates the expression of the photoreactivation gene PHR1, the demethylation at H3K36 is linked to UV sensitivity. Overexpression of Rph1 and H3K36A mutant reduced histone acetylation at the URS, which implies a crosstalk between histone demethylation and acetylation at the PHR1 promoter. Rph1 is a repressor of the DNA repair gene PHR1. Rph1 is dissociated from the PHR1 promoter in response to DNA damage. Rad53 regulates the expression of PHR1 and dissociation of Rph1 in response to DNA damage. Activated Rad53 complex phosphorylates Rph1 and S652A-mutated Rph1 impairs the dissociation in response to DNA damage; Rph1 might be a regulatory node connecting different signal­ing pathways responding to environmental stresses. Rph1 is mainly a transcriptional repressor. Rph1-regulated genes respond to DNA damage and environmental stress. Microarray analysis, overview
Saccharomyces cerevisiae
General Information (protein specific)
General Information
Commentary
Organism
evolution
Rph1 is a histone demethylase containing a Jumonji C (JmjC) domain and belongs to the C2H2 zinc-finger protein family
Saccharomyces cerevisiae
malfunction
histone H3K36A mutant shows increased UV sensitivity. Deletion of rph1 leads to approximately 2fold enhancement of PHR1 under normal conditions. Overexpression of Rph1 reduces the expression of PHR1 and increased UV sensitivity. The catalytically deficient mutant H235A of Rph1 diminishes the repressive transcriptional effect on PHR1 expression, which indicates that histone demethylase activity contributes to transcriptional repression; more than 75% of Rph1-regulated genes show increased expression in the rph1-deletion mutant
Saccharomyces cerevisiae
additional information
Rph1 is a labile protein, and Rad53 negatively modulates Rph1 protein level. The JmjN domain is important in maintaining protein stability and the repressive effect of Rph1. Binding motif 5'-CCCCTWA-3', which resembles the stress re­sponse element, is overrepresented in the promoters of Rph1-repressed genes. JmjN and ZF domains of Rph1 are required for its function. Rph1 binds to gene promoters and is dissociated with DNA damage
Saccharomyces cerevisiae
physiological function
histone H3K36 demethylase Rph1/KDM4 regulates the expression of the photoreactivation gene PHR1, the demethylation at H3K36 is linked to UV sensitivity. Overexpression of Rph1 and H3K36A mutant reduced histone acetylation at the URS, which implies a crosstalk between histone demethylation and acetylation at the PHR1 promoter. Rph1 is a repressor of the DNA repair gene PHR1. Rph1 is dissociated from the PHR1 promoter in response to DNA damage. Rad53 regulates the expression of PHR1 and dissociation of Rph1 in response to DNA damage. Activated Rad53 complex phosphorylates Rph1 and S652A-mutated Rph1 impairs the dissociation in response to DNA damage; Rph1 might be a regulatory node connecting different signal­ing pathways responding to environmental stresses. Rph1 is mainly a transcriptional repressor. Rph1-regulated genes respond to DNA damage and environmental stress. Microarray analysis, overview
Saccharomyces cerevisiae
Expression (protein specific)
Organism
Commentary
Expression
Saccharomyces cerevisiae
checkpoint kinase Rad53 negatively modulates Rph1 protein level; the crucial checkpoint protein Rad53 acts as an upstream regulator of Rph1 and dominates the phosphorylation of Rph1 that is required for efficient PHR1 expression and the dissociation of Rph1
down
Saccharomyces cerevisiae
Rph1 is phosphorylated under oxidative stress, which leads to Rph1 dissociation and transcriptional activation. Rad53 may be the key kinase essential for Rph1 phosphorylation on oxidative stress with H2O2 treatment
up
Other publictions for EC 1.14.11.27
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
743916
Hancock
The activity of JmjC histone ...
Homo sapiens
ACS Chem. Biol.
12
1011-1019
2017
-
1
1
-
1
-
-
1
-
1
-
-
-
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
1
-
-
-
-
1
-
1
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
745949
An
HistoneH3 demethylase JMJD2A ...
Homo sapiens
Oncotarget
8
49093-49109
2017
-
-
1
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
744722
Morera
4-biphenylalanine- and 3-phen ...
Homo sapiens
ChemMedChem
11
2063-2083
2016
1
-
1
-
-
-
33
1
-
1
-
2
-
2
-
-
1
1
-
2
-
-
4
-
1
-
-
-
1
-
-
-
-
-
30
1
-
1
-
-
-
-
30
33
-
1
-
1
-
2
-
-
-
1
-
2
-
-
4
-
1
-
-
-
1
-
-
-
-
2
2
-
-
-
744785
Pedersen
Continual removal of H3K9 pro ...
Mus musculus, Mus musculus C57BL/6
EMBO J.
35
1550-1564
2016
-
-
1
-
-
-
-
-
2
1
-
8
-
5
-
-
-
-
-
1
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
4
2
-
8
-
-
-
-
-
2
-
-
8
-
-
-
-
-
-
-
-
-
-
3
6
-
-
-
745803
Gacek-Matthews
KdmA, a histone H3 demethylas ...
Aspergillus nidulans, Aspergillus nidulans WIM126
Mol. Microbiol.
96
839-860
2015
-
-
1
-
1
-
-
-
1
1
-
4
-
3
-
-
-
-
-
-
-
-
6
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
4
-
-
-
-
-
-
-
-
6
-
1
-
-
-
-
-
-
-
-
3
3
-
-
-
744589
Ryu
Yeast histone H3 lysine 4 dem ...
Saccharomyces cerevisiae
BMC Biol.
12
75
2014
-
-
1
-
1
-
-
-
-
1
-
7
-
3
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
3
-
7
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
3
9
-
-
-
745919
Kupershmit
KDM4C (GASC1) lysine demethyl ...
Homo sapiens
Nucleic Acids Res.
42
6168-6182
2014
-
-
1
-
3
-
-
-
2
-
-
4
-
5
-
-
-
-
-
4
-
-
5
1
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
4
-
-
-
-
-
4
-
-
4
-
-
-
-
-
16
-
-
5
4
-
-
-
-
-
-
-
-
-
3
12
-
-
-
724709
Black
KDM4A lysine demethylase induc ...
Homo sapiens
Cell
154
541-555
2013
-
-
1
-
2
-
-
-
1
-
-
1
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
724813
Crona
Gene regulation by the lysine ...
Drosophila melanogaster
Dev. Biol.
373
453-463
2013
-
-
1
-
2
-
-
-
1
-
-
1
-
3
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
724815
Ishimura
Jmjd5, an H3K36me2 histone dem ...
Mus musculus
Development
139
749-759
2012
-
-
1
-
2
-
-
-
1
-
-
1
-
3
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
4
4
-
-
-
725960
Del Rizzo
Crystal structure and function ...
Homo sapiens
Mol. Cell. Biol.
32
4044-4052
2012
-
-
1
1
-
-
-
-
-
-
-
1
-
2
-
-
1
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
3
3
-
-
-
726260
Pan
The histone demethylase Jhdm1a ...
Homo sapiens, Mus musculus, Mus musculus C57/BL6J
PLoS Genet.
8
e1002761
2012
-
-
2
-
3
-
-
-
-
-
-
6
-
62
-
-
-
-
-
3
-
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
3
-
-
-
-
-
-
-
-
6
-
-
-
-
-
3
-
-
10
-
-
-
-
-
-
-
-
-
-
5
5
-
-
-
726301
Lin
HP1a targets the Drosophila KD ...
Drosophila melanogaster
PLoS ONE
7
e39758
2012
1
-
1
-
2
-
-
-
1
-
-
1
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
712996
Peng
Molecular characterization of ...
Sus scrofa
Mol. Biol. Rep.
38
4697-4704
2011
-
-
1
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
724651
He
KDM2b/JHDM1b, an H3K36me2-spec ...
Homo sapiens
Blood
117
3869-3880
2011
-
-
-
-
1
-
-
-
1
-
-
1
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
725450
Hillringhaus
Structural and evolutionary ba ...
Homo sapiens
J. Biol. Chem.
286
41616-41625
2011
-
-
1
1
-
-
-
-
1
1
-
5
-
6
-
-
1
-
-
-
-
-
12
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
1
-
-
-
-
-
-
3
3
-
5
-
-
-
3
-
-
-
-
12
-
-
-
-
-
-
-
-
-
-
2
6
-
-
-
726071
Liang
The histone H3K36 demethylase ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4742
Nucleic Acids Res.
39
4151-4165
2011
-
-
1
-
1
1
1
-
2
-
-
6
-
24
-
1
-
-
-
-
-
-
6
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
1
-
1
-
-
2
-
-
6
-
-
1
-
-
-
-
-
6
-
1
-
-
-
1
-
-
-
2
4
4
2
-
-
726379
Fnu
Methylation of histone H3 lysi ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
108
540-545
2011
-
-
-
-
-
-
-
-
1
-
-
1
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
711153
Chang
Crystal structure of the catal ...
Saccharomyces cerevisiae
Biochem. J.
433
295-302
2010
-
-
-
1
-
-
-
1
-
1
-
4
-
3
-
-
-
-
-
-
-
-
7
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
1
-
4
-
-
-
-
-
-
-
-
7
1
1
-
-
-
1
-
-
-
-
1
1
-
-
-
711823
Strobl-Mazzulla
Histone demethylase JmjD2A reg ...
Gallus gallus
Dev. Cell
19
460-468
2010
-
-
1
-
1
-
-
-
1
-
-
2
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
696434
Marmorstein
Histone modifying enzymes: str ...
Homo sapiens
Biochim. Biophys. Acta
1789
58-68
2009
-
-
-
1
1
-
2
-
-
1
-
3
-
1
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
2
-
-
-
1
-
3
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697140
Li
Alterations of histone modific ...
Homo sapiens
Carcinogenesis
30
1243-1251
2009
1
-
1
-
-
-
1
-
-
1
-
1
-
2
-
-
-
-
-
4
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
-
1
-
1
-
-
-
-
-
4
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
701212
Lan
Epigenetic regulation: methyla ...
Drosophila melanogaster
Sci. China C Life Sci.
52
311-322
2009
1
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689255
Lloret-Llinares
Characterization of Drosophila ...
Drosophila melanogaster
Nucleic Acids Res.
36
2852-2863
2008
-
-
1
-
-
-
-
-
1
1
-
4
-
5
-
-
-
-
-
-
-
-
9
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
-
4
-
-
-
-
-
-
-
-
9
1
-
-
-
-
-
-
-
-
1
1
1
1
-
-
689797
Pfau
Members of a family of JmjC do ...
Rattus norvegicus
Proc. Natl. Acad. Sci. USA
105
1907-1912
2008
-
-
1
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
698109
Lagarou
dKDM2 couples histone H2A ubiq ...
Drosophila melanogaster
Genes Dev.
22
2799-2810
2008
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
698354
Cui
Histone lysine methyltransfera ...
Plasmodium falciparum
Int. J. Parasitol.
38
1083-1097
2008
-
-
1
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
700162
Polytarchou
The JmjC domain histone demeth ...
Mus musculus, Mus musculus C57BL/6
Mol. Cell. Biol.
28
7451-7464
2008
-
-
1
-
1
-
-
-
-
-
-
-
-
140
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
700202
Wallrath
Stimulating conversations betw ...
Drosophila melanogaster
Mol. Cell
32
601-602
2008
1
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
700209
Lin
Heterochromatin protein 1a sti ...
Drosophila melanogaster
Mol. Cell
32
696-706
2008
2
-
1
-
2
-
-
-
1
1
-
2
-
3
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
2
-
-
-
-
-
1
1
-
2
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
700374
He
The H3K36 demethylase Jhdm1b/K ...
Mus musculus
Nat. Struct. Mol. Biol.
15
1169-1175
2008
-
-
1
-
1
-
-
-
-
-
-
2
-
2
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
687571
Kim
Two Saccharomyces cerevisiae J ...
Saccharomyces cerevisiae
J. Biol. Chem.
282
20827-20835
2007
-
-
-
-
1
-
-
-
-
-
-
3
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688966
Fang
The Saccharomyces cerevisiae h ...
Saccharomyces cerevisiae
Mol. Cell. Biol.
27
5055-5065
2007
1
-
1
-
4
-
-
-
-
1
2
-
-
2
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
4
-
-
-
-
-
-
1
2
-
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689144
Couture
Specificity and mechanism of J ...
Homo sapiens
Nat. Struct. Mol. Biol.
14
689-695
2007
-
-
1
1
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
1
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
689151
Ng
Crystal structures of histone ...
Homo sapiens
Nature
448
87-91
2007
-
-
-
1
-
-
-
-
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689746
Chen
Structural basis of the recogn ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
104
10818-10823
2007
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
662947
Tsukada
Histone demethylation by a fam ...
Homo sapiens, Saccharomyces cerevisiae
Nature
439
811-816
2006
1
-
-
-
2
-
-
-
1
1
-
-
-
4
-
-
1
-
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
1
1
-
-
-
-
-
1
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-