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Literature summary for 1.14.11.27 extracted from

  • Zhou, J.; Wang, F.; Xu, C.; Zhou, Z.; Zhang, W.
    The histone demethylase JMJD2A regulates the expression of BDNF and mediates neuropathic pain in mice (2017), Exp. Cell Res., 361, 155-162 .
    View publication on PubMed
Search for more literature for 1.14.11.27

Application

Application Comment Organism
medicine JMJD2A overexpression increases the mRNA and protein level of brain-derived neurotrophic factor Bdnf, a protein critically involved in neuropathic pain. JMJD2A binds to the promoter of Bdnf and demethylates H3K9me3 and H3K36me3 at the Bdnf promoter to promote the expression of Bdnf Homo sapiens
medicine JMJD2A responds to neuropathic pain and participates in the maintenance of neuropathic pain. The mRNA and protein levels of Jmjd2a are significantly increased in the neurons of mouse undergoing neuropathic pain. Jmjd2a responds to 5-hydroxytryptamine and promotes the expression of the brain-derived neurotrophic factor (Bdnf), a protein critically involved in neuropathic pain. JMJD2A binds to the promoter of Bdnf and demethylates H3K9me3 and H3K36me3 at the Bdnf promoter to promote the expression of Bdnf. JMJD2A promotes the expression of Bdnf during neuropathic pain and neuron-specific knockout of Jmjd2a blocks the hypersensitivity of mice undergoing chronic neuropathic pain Mus musculus

Protein Variants

Protein Variants Comment Organism
H188A inactive Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O75164 cf. EC 1.14.11.65, EC 1.14.11.66, EC 1.14.11.69
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Mus musculus Q8BW72 cf. EC 1.14.11.65, EC 1.14.11.66, EC 1.14.11.69
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Synonyms

Synonyms Comment Organism
JMJD2A
-
 Homo sapiens
JMJD2A
-
 Mus musculus
KDM4A
-
 Homo sapiens
KDM4A
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus mRNA and protein levels of Jmjd2a are significantly increased in the neurons of mouse undergoing neuropathic pain up

General Information

General Information Comment Organism
physiological function catalyzes the demethylation of di- and trimethylated Lys9 (reactions of EC 1.14.11.65 and 1.14.11.66) and Lys36 in histone H3 (reactions of EC 1.14.11.27 and 1.14.11.69). Jmjd2a responds to 5-hydroxytryptamine and promotes the expression of the brain-derived neurotrophic factor (Bdnf), a protein critically involved in neuropathic pain. JMJD2A binds to the promoter of Bdnf and demethylates H3K9me3 and H3K36me3 at the Bdnf promoter to promote the expression of Bdnf Homo sapiens
physiological function catalyzes the demethylation of di- and trimethylated Lys9 (reactions of EC 1.14.11.65 and 1.14.11.66) and Lys36 in histone H3 (reactions of EC 1.14.11.27 and 1.14.11.69). Jmjd2a responds to 5-hydroxytryptamine and promotes the expression of the brain-derived neurotrophic factor (Bdnf), a protein critically involved in neuropathic pain. JMJD2A binds to the promoter of Bdnf and demethylates H3K9me3 and H3K36me3 at the Bdnf promoter to promote the expression of Bdnf. JMJD2A promotes the expression of Bdnf during neuropathic pain and neuron-specific knockout of Jmjd2a blocks the hypersensitivity of mice undergoing chronic neuropathic pain Mus musculus