Literature summary for 1.14.11.4 extracted from

  • Webby, C.J.; Wolf, A.; Gromak, N.; Dreger, M.; Kramer, H.; Kessler, B.; Nielsen, M.L.; Schmitz, C.; Butler, D.S.; Yates, J.R.; Delahunty, C.M.; Hahn, P.; Lengeling, A.; Mann, M.; Proudfoot, N.J.; Schofield, C.J.; Boettger, A.
    Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing (2009), Science, 325, 90-93.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of GFP-tagged Jmjd6 in HEK-293 cells, GFP pulldown interaction analysis with U2AF65, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens
-
-
nucleus
-
Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ dependent on Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens Jmjd6 changes alternative RNA splicing of some, but not all, of the endogenous and reporter genes, supporting a specific role for Jmjd6 in the regulation of RNA splicing, overview ?
-
?
L-lysine-[U2AF65] + 2-oxoglutarate + O2 Homo sapiens U2AF65 is the splicing factor U2 small nuclear ribonucleoprotein auxiliary factor 65-kDa subunit, which undergoes posttranslational lysyl-5-hydroxylation catalyzed by the Fe2+ and 2-oxoglutarate-dependent dioxygenase Jumonji domain-6 protein Jmjd6, a nuclear protein that has an important role in vertebrate development and is a human homologue of the HIF asparaginyl-hydroxylase 5-hydroxy-L-lysine-[U2AF65] + succinate + CO2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information posttranslational hydroxylation in both the cytoplasm and the nucleoplasm is ubiquitous Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Jmjd6 changes alternative RNA splicing of some, but not all, of the endogenous and reporter genes, supporting a specific role for Jmjd6 in the regulation of RNA splicing, overview Homo sapiens ?
-
?
L-lysine-[U2AF65] + 2-oxoglutarate + O2 U2AF65 is the splicing factor U2 small nuclear ribonucleoprotein auxiliary factor 65-kDa subunit, which undergoes posttranslational lysyl-5-hydroxylation catalyzed by the Fe2+ and 2-oxoglutarate-dependent dioxygenase Jumonji domain-6 protein Jmjd6, a nuclear protein that has an important role in vertebrate development and is a human homologue of the HIF asparaginyl-hydroxylase Homo sapiens 5-hydroxy-L-lysine-[U2AF65] + succinate + CO2
-
?
L-lysine-[U2AF65] + 2-oxoglutarate + O2 U2AF65 is the splicing factor U2 small nuclear ribonucleoprotein auxiliary factor 65-kilodalton subunit Homo sapiens 5-hydroxy-L-lysine-[U2AF65] + succinate + CO2
-
?

Synonyms

Synonyms Comment Organism
Jmjd6
-
Homo sapiens