BRENDA - Enzyme Database show
show all sequences of 1.14.11.51

DNA methylation on N6-adenine in C. elegans

Greer, E.L.; Blanco, M.A.; Gu, L.; Sendinc, E.; Liu, J.; Aristizabal-Corrales, D.; Hsu, C.H.; Aravind, L.; He, C.; Shi, Y.; Cell 161, 868-878 (2015)

Data extracted from this reference:

Engineering
Amino acid exchange
Commentary
Organism
D186A
inactive
Caenorhabditis elegans
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
N6-methyladenine in DNA + 2-oxoglutarate + O2
Caenorhabditis elegans
-
adenine in DNA + formaldehyde + succinate + CO2
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Caenorhabditis elegans
-
N2 Bristol
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
N6-methyladenine in DNA + 2-oxoglutarate + O2
-
742235
Caenorhabditis elegans
adenine in DNA + formaldehyde + succinate + CO2
-
-
-
?
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
D186A
inactive
Caenorhabditis elegans
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
N6-methyladenine in DNA + 2-oxoglutarate + O2
Caenorhabditis elegans
-
adenine in DNA + formaldehyde + succinate + CO2
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
N6-methyladenine in DNA + 2-oxoglutarate + O2
-
742235
Caenorhabditis elegans
adenine in DNA + formaldehyde + succinate + CO2
-
-
-
?
General Information
General Information
Commentary
Organism
malfunction
enzyme deletion accelerates the progressive fertility defect of spr-5 mutant worms
Caenorhabditis elegans
General Information (protein specific)
General Information
Commentary
Organism
malfunction
enzyme deletion accelerates the progressive fertility defect of spr-5 mutant worms
Caenorhabditis elegans
Other publictions for EC 1.14.11.51
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
736883
Wu
DNA methylation on N-adenine i ...
Mus musculus
Nature
532
329-333
2016
-
-
-
-
1
-
-
-
-
1
1
1
-
3
-
-
-
-
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
1
1
-
-
-
-
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
742207
Zhou
DNA N6-methyladenine demethyl ...
Homo sapiens
Bone Res.
4
16033
2016
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
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-
-
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-
-
-
-
1
-
-
-
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-
1
-
-
1
-
-
-
-
-
-
-
-
-
1
2
2
1
-
-
738025
Zhang
N6-methyladenine DNA modificat ...
Drosophila melanogaster
Cell
161
893-906
2015
-
-
-
-
-
-
-
-
-
-
1
1
-
5
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
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-
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-
-
-
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-
-
-
-
-
1
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
742235
Greer
DNA methylation on N6-adenine ...
Caenorhabditis elegans
Cell
161
868-878
2015
-
-
-
-
1
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
1
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1
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1
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-
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-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
738971
Ye
-
Repair of methyl lesions in RN ...
Homo sapiens
MedChemComm
5
1797-1803
2014
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
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-
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1
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1
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1
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