Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P0CB42 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone marrow | - |
Mus musculus | - |
bone marrow stem cell | - |
Mus musculus | - |
General Information | Comment | Organism |
---|---|---|
physiological function | Alkbh1 expression in bone marrow mesenchymal stem cells declines during aging. Knockout of Alkbh1 promotes adipogenic differentiation of bone marrow mesenchymal stem cells while inhibits osteogenic differentiation. Bone marrow mesenchymal stem cells -specific Alkbh1 knockout mice exhibit reduced bone mass and increased marrow adiposity. Overexpression of Alkbh1 attenuates bone loss and marrow fat accumulation in aged mice | Mus musculus |