Cloned (Comment) | Organism |
---|---|
short isoform of JMJD2A expression analysis, overview | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | siRNA silencing of DELTAN-JMJD2A results in drastic impairment of MHC expression and myotube formation, the Myog promoter is a specific target of DElTAN-JMJD2A. Genome-wide expression profiling and exon-specific siRNA knockdown indicate that, in contrast to the full-length protein, N-terminal demethylase domainis necessary for myotube formation and muscle-specific gene expression | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 | Homo sapiens | - |
histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
muscle | short isoform of JMJD2A is upregulated during muscle differentiation, expression analysis and pattern, overview | Homo sapiens | - |
myotube | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 | - |
Homo sapiens | histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
histone demethylase | - |
Homo sapiens |
JMJD2A/KDM4A | - |
Homo sapiens |
Jumonji domaincontaining demethylase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | short isoform of JMJD2A is upregulated during muscle differentiation | up |
General Information | Comment | Organism |
---|---|---|
evolution | the enzyme belongs to the JMJD2/KDM4 subfamily (JMJD2A, B, C and D) specifically demethylates H3K9 and H3K36 either di- or trimethylated | Homo sapiens |
physiological function | Derepression of the promoter of the gene encoding the myogenic factor myogenin (Myog) is key for initiation of muscle differentiation, mechanism of H3K9 demethylation at the Myog promoter, overview. Genome-wide expression profiling and exon-specific siRNA knockdown indicate that, in contrast to the full-length protein, N-terminal demethylase domainis necessary for myotube formation and muscle-specific gene expression. promotes MyoD-induced conversion of NIH3T3 cells into muscle cells. ChIP-on-chip analysis indicates that DN-JMJD2A binds to genes mainly involved in transcriptional control and that this binding is linked to gene activation. DN-JMJD2A is recruited to the Myog promoter at the onset of differentiation. This binding is essential to promote the demethylation of H3K9me2 and H3K9me3 | Homo sapiens |