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Literature summary for 1.14.11.67 extracted from

  • Zhang, Y.Z.; Zhang, Q.H.; Ye, H.; Zhang, Y.; Luo, Y.M.; Ji, X.M.; Su, Y.Y.
    Distribution of lysine-specific demethylase 1 in the brain of rat and its response in transient global cerebral ischemia (2010), Neurosci. Res., 68, 66-72.
    View publication on PubMed
Search for more literature for 1.14.11.67

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Rattus norvegicus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
histone H3 N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2 Rattus norvegicus
-
 histone H3 N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
-
 ?
histone H3 N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2 Rattus norvegicus Sprague-Dawley
-
 histone H3 N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
-
 ?
histone H3 N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2 Rattus norvegicus
-
 histone H3 N6-methyl-L-lysine4 + succinate + formaldehyde + CO2
-
 ?
histone H3 N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2 Rattus norvegicus Sprague-Dawley
-
 histone H3 N6-methyl-L-lysine4 + succinate + formaldehyde + CO2
-
 ?
histone H3 N6-methyl-L-lysine4 + 2-oxoglutarate + O2 Rattus norvegicus
-
 histone H3 L-lysine4 + succinate + formaldehyde + CO2
-
 ?
histone H3 N6-methyl-L-lysine4 + 2-oxoglutarate + O2 Rattus norvegicus Sprague-Dawley
-
 histone H3 L-lysine4 + succinate + formaldehyde + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Rattus norvegicus Sprague-Dawley
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
amygdala
-
 Rattus norvegicus
-
brain the distributions of H3-K4 mono-, di-, and tri-methylated histones exhibit exactly the same pattern as the LSD1 protein, immunofluoresecence histochemic analysis, overview Rattus norvegicus
-
cerebral cortex
-
 Rattus norvegicus
-
corpus striatum
-
 Rattus norvegicus
-
hippocampus
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
histone H3 N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
-
 Rattus norvegicus histone H3 N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
-
 ?
histone H3 N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
-
 Rattus norvegicus Sprague-Dawley histone H3 N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
-
 ?
histone H3 N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
-
 Rattus norvegicus histone H3 N6-methyl-L-lysine4 + succinate + formaldehyde + CO2
-
 ?
histone H3 N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
-
 Rattus norvegicus Sprague-Dawley histone H3 N6-methyl-L-lysine4 + succinate + formaldehyde + CO2
-
 ?
histone H3 N6-methyl-L-lysine4 + 2-oxoglutarate + O2
-
 Rattus norvegicus histone H3 L-lysine4 + succinate + formaldehyde + CO2
-
 ?
histone H3 N6-methyl-L-lysine4 + 2-oxoglutarate + O2
-
 Rattus norvegicus Sprague-Dawley histone H3 L-lysine4 + succinate + formaldehyde + CO2
-
 ?

Synonyms

Synonyms Comment Organism
LSD1
-
 Rattus norvegicus
lysine-specific demethylase 1
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus LSD1 expression in the brain is induced both region and cell specifically after ischemic/perfusion up

General Information

General Information Comment Organism
physiological function The lysine-specific histone demethylase 1 is a chromatin modifying enzyme that specifically removes methyl groups from lysine 4 of histone 3 and induces transcriptional repression. Tightly regulated distribution for LSD1 in the brain of rats under ischemic insult, suggesting a critical role in neuron function, overview Rattus norvegicus