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Literature summary for 1.14.13.168 extracted from

  • Uc-Chuc, M.A.; Ku-Gonzalez, A.F.; Jimenez-Ramirez, I.A.; Loyola-Vargas, V.M.
    Identification, analysis, and modeling of the YUCCA protein family genome-wide in Coffea canephora (2022), Proteins, 90, 1005-1024 .
    View publication on PubMed
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Crystallization (Commentary)

Crystallization (Comment) Organism
molecular docking of FAD, NADPH, indole pyruvic acid, and yucasin to isoform YUC2. Indole pyruvic acid is located near the flavin of the prosthetic group FAD close to the small domain Coffea canephora

Protein Variants

Protein Variants Comment Organism
G186A mutation in isoform YUC4, destabilizing Coffea canephora
G188A mutation in isoform YUC2, destabilizing Coffea canephora
G190W mutation in isoform YUC2, destabilizing Coffea canephora
G191P mutation in isoform YUC2, destabilizing Coffea canephora
G193A mutation in isoform YUC2, destabilizing Coffea canephora
N189P mutation in isoform YUC4, destabilizing Coffea canephora
N191P mutation in isoform YUC2, destabilizing Coffea canephora

Inhibitors

Inhibitors Comment Organism Structure
yucasin in isoform YUC2, yucasin competes for the same site as indole pyruvic acid, blocking indole acetic acid production Coffea canephora

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm isoforms YUC1, YUC3, YUC6, YUC8, YUC10, YUC11 Coffea canephora 5737
-
endoplasmic reticulum isoform YUC4 Coffea canephora 5783
-
extracellular isoforms YUC3, YUC5 Coffea canephora
-
-
mitochondrion isoform YUC2 Coffea canephora 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
indole-3-pyruvic acid binds very close to FAD along the big domain, and yucasin competes for the same site as indole pyruvic acid, blocking indole acetic acid production Coffea canephora

Organism

Organism UniProt Comment Textmining
Coffea canephora
-
-
-

Synonyms

Synonyms Comment Organism
Cc06_g09670 gene name, isoform YUC2 Coffea canephora

Cofactor

Cofactor Comment Organism Structure
FAD required, binds at the big domain site in isoform YUC2. FAD is close to the nucleotide-binding motif Gly19, Ala20, Gly21, Pro22, Ser23, and Gly24, located in the first strand-turn-helix motif at the core of the big domain Coffea canephora
NADPH required, binds at the small domain site in isoform YUC2. NADPH cofactor is bound to the second nucleotide-binding motif, Gly188, Cys189, Gly190, Asn191, Ser192, and Gly193, which is located at the strand-turn-helix motif within the small domain Coffea canephora

General Information

General Information Comment Organism
physiological function 10 members of the YUC gene family are found in Coffea canephora. The YUC enzymes require the prosthetic group FAD and the cofactor NADPH for their enzymatic activity. Indole-3-pyruvic acid binds very close to FAD along the big domain Coffea canephora