Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | the enzyme contains both a non-haem iron and an Fe-S centre | Rhodobacter capsulatus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
precorrin-3A + NADH + O2 | Rhodobacter capsulatus | the enzyme is involved in ring contraction, whereby an integral carbon atom of the tetrapyrrole-derived macrocycle is removed, and cobalt chelation during aerobic synthesis of vitamin B12, the catalytic cycle of CobZ, overview | precorrin-3B + NAD+ + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rhodobacter capsulatus | - |
in bacteria such as Rhodobacter capsulatus CobG is substituted by an isofunctional protein called CobZ | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
precorrin-3A + NADH + H+ + O2 = precorrin-3B + NAD+ + H2O | reaction mechanism of CobZ | Rhodobacter capsulatus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
precorrin-3A + NADH + O2 | the enzyme is involved in ring contraction, whereby an integral carbon atom of the tetrapyrrole-derived macrocycle is removed, and cobalt chelation during aerobic synthesis of vitamin B12, the catalytic cycle of CobZ, overview | Rhodobacter capsulatus | precorrin-3B + NAD+ + H2O | - |
? | |
precorrin-3A + NADH + O2 | the enzyme generates a hydroxy lactone intermediate | Rhodobacter capsulatus | precorrin-3B + NAD+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CobZ | - |
Rhodobacter capsulatus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
flavin | enzyme-bound | Rhodobacter capsulatus |