Application | Comment | Organism |
---|---|---|
medicine | increased adipose tissue aromatase activity reduces adipose tissue inflammation and improves insulin sensitivity in male mice | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P28649 | - |
- |
Source Tissue | Comment | Organism | Textmining |
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General Information | Comment | Organism |
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metabolism | in a male mouse model overexpressing the aromatase enzyme, adipose tissue estradiol levels are increased while circulating sex steroid levels are unaffected. The overexpressing male mice are more insulin sensitive compared with wild-type mice and exhibit increased serum adiponectin levels and upregulated expression of Glut4 and Irs1 in white adipose tissue. The expression of markers of macrophages and immune cell infiltration is markedly decreased in their white adipose tissue | Mus musculus |