Protein Variants | Comment | Organism |
---|---|---|
A105L | mutant has reduced progesterone 16alpha-hydroxylase activity. Catalyzes the 16alpha,17-epoxidation and the ordinarily minor 21-hydroxylation of 16,17-dehydroprogesterone in a 1:5 ratio of epoxide:21-hydroxylated products | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P05093 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
16,17-dehydropregnenolone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
16,17-dehydroprogesterone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
additional information | CYP17A1 wild-type and mutation A105L do not hydroxylate pregnenolone in 21- or 16alpha-position | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
P450c17 | - |
Homo sapiens |