BRENDA - Enzyme Database show
show all sequences of 1.14.14.73

Albendazole sulfonation by rat liver cytochrome P-450c

Souhaili-El Amri, H.; Mothe, O.; Totis, M.; Masson, C.; Batt, A.M.; Delatour, P.; Siest, G.; J. Pharmacol. Exp. Ther. 246, 758-764 (1988)

Data extracted from this reference:

Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Rattus norvegicus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
bile
in bile of albendazole-treated animals, only albendazole S-oxide, but not the sulfone, is present
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
bile
in bile of albendazole-treated animals, only albendazole S-oxide, but not the sulfone, is present
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
Expression
Organism
Commentary
Expression
Rattus norvegicus
cytochrome P-450c is induced potently in vivo by albendazole
up
General Information
General Information
Commentary
Organism
physiological function
in liver perfusion fluid of albendazole-treated animals, the concentration of albendazole-sulfoxide remains unchanged, as compared to control animals, whereas albendazole-sulfone is increased in treated animals
Rattus norvegicus
General Information (protein specific)
General Information
Commentary
Organism
physiological function
in liver perfusion fluid of albendazole-treated animals, the concentration of albendazole-sulfoxide remains unchanged, as compared to control animals, whereas albendazole-sulfone is increased in treated animals
Rattus norvegicus
Expression (protein specific)
Organism
Commentary
Expression
Rattus norvegicus
cytochrome P-450c is induced potently in vivo by albendazole
up
Other publictions for EC 1.14.14.73
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
744771
Gul
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2
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2
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2
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2
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-
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-
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744049
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1
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2
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2
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2
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2
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744770
Lee
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Homo sapiens
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38
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2010
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1
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1
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1
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8
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1
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1
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8
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744610
Rawden
Relative contribution of cyto ...
Homo sapiens
Br. J. Clin. Pharmacol.
49
313-322
2000
-
-
-
-
-
-
2
-
1
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1
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1
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1
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1
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1
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2
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1
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1
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1
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1
1
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744768
Moroni
Chiral sulfoxidation of alben ...
Rattus norvegicus
Drug Metab. Dispos.
23
160-165
1995
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-
-
-
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-
1
-
1
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1
-
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1
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1
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1
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1
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1
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1
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1
1
-
-
-
745602
Souhaili-El Amri
Albendazole sulfonation by ra ...
Rattus norvegicus
J. Pharmacol. Exp. Ther.
246
758-764
1988
-
-
-
-
-
-
-
-
-
-
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1
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2
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2
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1
1
1
1
-
-
746557
Souhaili El Amri
Sulphoxidation of albendazole ...
Sus scrofa
Xenobiotica
17
1159-1174
1987
-
-
-
-
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1
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1
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1
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1
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1
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1
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1
1
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