BRENDA - Enzyme Database show
show all sequences of 1.14.14.78

Role of human CYP4F2 in hepatic catabolism of the proinflammatory agent leukotriene B4

Jin, R.; Koop, D.R.; Raucy, J.L.; Lasker, J.M.; Arch. Biochem. Biophys. 359, 89-98 (1998)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
additional information
unaffected by lauric acid, palmitic acid, and prostaglandin F2alpha
Homo sapiens
prostaglandin A1
-
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Homo sapiens
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Purification (Commentary)
Commentary
Organism
tryptamine CH-Sepharose column chromatography, DE-53 cellulose column chromatography, and Hypatite C column chromatography
Homo sapiens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
arachidonic acid + [reduced NADPH-hemoprotein reductase] + O2
-
729093
Homo sapiens
20-hydroxyarachidonic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
-
729093
Homo sapiens
20-hydroxyleukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
Cofactor
Cofactor
Commentary
Organism
Structure
NADPH
-
Homo sapiens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADPH
-
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
additional information
unaffected by lauric acid, palmitic acid, and prostaglandin F2alpha
Homo sapiens
prostaglandin A1
-
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Homo sapiens
-
-
Purification (Commentary) (protein specific)
Commentary
Organism
tryptamine CH-Sepharose column chromatography, DE-53 cellulose column chromatography, and Hypatite C column chromatography
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
arachidonic acid + [reduced NADPH-hemoprotein reductase] + O2
-
729093
Homo sapiens
20-hydroxyarachidonic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
-
729093
Homo sapiens
20-hydroxyleukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
General Information
General Information
Commentary
Organism
physiological function
CYP4F2 is the principle leukotriene B4 omega-hydroxylating enzyme expressed in human liver and plays an important role in regulating circulating as well as hepatic levels of this powerful proinflammatory eicosanoid
Homo sapiens
General Information (protein specific)
General Information
Commentary
Organism
physiological function
CYP4F2 is the principle leukotriene B4 omega-hydroxylating enzyme expressed in human liver and plays an important role in regulating circulating as well as hepatic levels of this powerful proinflammatory eicosanoid
Homo sapiens
Other publictions for EC 1.14.14.78
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
729243
Edson
Cytochrome P450-dependent cata ...
Homo sapiens
Biochemistry
52
8276-8285
2013
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1
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730420
Farley
omega-Hydroxylation of phylloq ...
Rattus norvegicus
Mol. Nutr. Food Res.
57
1785-1793
2013
-
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1
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729992
Bardowell
Disruption of mouse cytochrome ...
Mus musculus
J. Biol. Chem.
287
26077-26086
2012
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1
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2
2
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729098
Tang
Human cytochrome P450 4F11: He ...
Homo sapiens
Arch. Biochem. Biophys.
494
86-93
2010
-
-
1
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4
-
1
1
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4
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1
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1
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1
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4
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1
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4
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1
1
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1
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4
1
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4
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4
4
730151
Dhar
Omega oxidation of 3-hydroxy f ...
Homo sapiens
J. Lipid Res.
49
612-624
2008
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-
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2
-
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728972
Parker
Discovery, characterization, a ...
Homo sapiens
Ann. N. Y. Acad. Sci.
1031
13-21
2004
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729122
Zhang
Regulation of CYP4F2 leukotrie ...
Homo sapiens
Biochem. Biophys. Res. Commun.
279
864-871
2000
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1
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3
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1
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3
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1
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1
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729093
Jin
Role of human CYP4F2 in hepati ...
Homo sapiens
Arch. Biochem. Biophys.
359
89-98
1998
-
-
-
-
-
-
2
-
1
-
-
-
-
1
-
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1
-
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1
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2
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1
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1
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1
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1
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2
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1
1
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730249
Powell
Metabolism of arachidonic acid ...
Homo sapiens
J. Pharmacol. Exp. Ther.
285
1327-1336
1998
-
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1
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