Cloned (Comment) | Organism |
---|---|
expression of CYP11B2 in Schizosaccharomyces pombe and in V79 MZh cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(1H-inden-2-yl)-1H-imidazole | CYP11B2 IC50: 448 nM, no inhibition of CYP11B1, recombinant enzymes | Homo sapiens | |
1-(3,4-dihydronaphthalen-2-yl)-1H-imidazole | CYP11B1 IC50: 639 nM, CYP11B2 IC50: 334 nM, recombinant enzymes | Homo sapiens | |
1-(6-methoxy-3,4-dihydronaphthalen-2-yl)-1H-imidazole | CYP11B1 IC50: 763 nM, CYP11B2 IC50: 411 nM, recombinant enzymes | Homo sapiens | |
3-(1-ethyl-3,4-dihydronaphthalen-2-yl)-pyridine | CYP11B1 IC50: 2117 nM, CYP11B2 IC50: 30 nM, recombinant enzymes | Homo sapiens | |
3-(1-methyl-3,4-dihydronaphthalen-2-yl)-pyridine | CYP11B1 IC50: 1268 nM, CYP11B2 IC50: 7 nM, recombinant enzymes | Homo sapiens | |
3-(3,4-dihydronaphthalen-2-yl)pyridine | CYP11B1 IC50: 1729 nM, CYP11B2 IC50: 7 nM, recombinant enzymes | Homo sapiens | |
3-(3-methyl-3,4-dihydronaphthalen-2-yl)pyridine | CYP11B1 IC50: 503 nM, CYP11B2 IC50: 5 nM, recombinant enzymes | Homo sapiens | |
3-(4-ethyl-3,4-dihydronaphthalen-2-yl)pyridine | CYP11B1 IC50: 1615 nM, CYP11B2 IC50: 176 nM, recombinant enzymes | Homo sapiens | |
3-(4-methyl-3,4-dihydronaphthalen-2-yl)pyridine | CYP11B1 IC50: 1291 nM, CYP11B2 IC50: 13 nM, recombinant enzymes | Homo sapiens | |
3-(6-methoxy-1H-inden-2-yl)pyridine | competitive, CYP11B1 IC50: 5684 nM, CYP11B2 IC50: 4 nM, recombinant enzymes | Homo sapiens | |
3-(6-methoxy-3,4-dihydronaphthalen-2-yl)pyridine | competitive, CYP11B1 IC50: 578 nM, CYP11B2 IC50: 2 nM, recombinant enzymes | Homo sapiens | |
3-(7-methoxy-3,4-dihydronaphthalen-2-yl)pyridine | CYP11B2 IC50: 45 nM, no inhibition of CYP11B1, recombinant enzymes | Homo sapiens | |
3-[(Z)-2-phenylvinyl]pyridine | CYP11B1 IC50: 288 nM, CYP11B2 IC50: 735 nM, no inhibition by the 3-[(E)-2-phenylvinyl]pyridine isomer, recombinant enzymes | Homo sapiens | |
4-(6-methoxy-3,4-dihydronaphthalen-2-yl)pyridine | CYP11B1 IC50: 2529 nM, CYP11B2 IC50: 2834 nM, recombinant enzymes | Homo sapiens | |
6-methoxydihydronaphthalene | - |
Homo sapiens | |
atenolol | potent inhibition of CYP11B2, recombinant enzyme | Homo sapiens | |
erythromycin | potent inhibition of CYP11B2, recombinant enzyme | Homo sapiens | |
fadrozole | CYP11B2 IC50: 1 nM, CYP11B1 IC50: 10 nM, recombinant enzymes | Homo sapiens | |
ketoconazole | CYP11B2 IC50: 81 nM, CYP11B1 IC50: 224 nM, recombinant enzymes | Homo sapiens | |
ketoprofene | potent inhibition of CYP11B2, recombinant enzyme | Homo sapiens | |
additional information | synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of CYP11B2 for the treatment of congestive heart failure and myocardial fibrosis, ligand-protein interactions, docking and molecular dynamics studies using homology-modeled CYP11B2 structure, overview | Homo sapiens | |
testosterone | potent inhibition of CYP11B2, recombinant enzyme | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-deoxycortisol + reduced adrenal ferredoxin + O2 | Homo sapiens | CYP11B1 | cortisol + oxidized adrenal ferredoxin + H2O | - |
? | |
18-hydroxycorticosterone + reduced adrenal ferredoxin + O2 | Homo sapiens | CYP11B2 | aldosterone + oxidized adrenal ferredoxin + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-deoxycortisol + reduced adrenal ferredoxin + O2 | CYP11B1 | Homo sapiens | cortisol + oxidized adrenal ferredoxin + H2O | - |
? | |
18-hydroxycorticosterone + reduced adrenal ferredoxin + O2 | CYP11B2 | Homo sapiens | aldosterone + oxidized adrenal ferredoxin + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Aldosterone synthase | - |
Homo sapiens |
CYP11B1 | - |
Homo sapiens |
CYP11B2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
reduced adrenal ferredoxin | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000013 | - |
6-methoxydihydronaphthalene | recombinant enzyme | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000001 | - |
CYP11B2 IC50: 1 nM | Homo sapiens | fadrozole | |
0.000002 | - |
CYP11B2 IC50: 2 nM, recombinant enzymes | Homo sapiens | 3-(6-methoxy-3,4-dihydronaphthalen-2-yl)pyridine | |
0.000004 | - |
CYP11B2 IC50: 4 nM, recombinant enzymes | Homo sapiens | 3-(6-methoxy-1H-inden-2-yl)pyridine | |
0.000005 | - |
CYP11B2 IC50: 5 nM, recombinant enzymes | Homo sapiens | 3-(3-methyl-3,4-dihydronaphthalen-2-yl)pyridine | |
0.000007 | - |
CYP11B2 IC50: 7 nM, recombinant enzymes | Homo sapiens | 3-(3,4-dihydronaphthalen-2-yl)pyridine | |
0.000007 | - |
CYP11B2 IC50: 7 nM, recombinant enzymes | Homo sapiens | 3-(1-methyl-3,4-dihydronaphthalen-2-yl)-pyridine | |
0.00001 | - |
CYP11B1 IC50: 10 nM, recombinant enzymes | Homo sapiens | fadrozole | |
0.000013 | - |
, CYP11B2 IC50: 13 nM, recombinant enzymes | Homo sapiens | 3-(4-methyl-3,4-dihydronaphthalen-2-yl)pyridine | |
0.00003 | - |
CYP11B2 IC50: 30 nM, recombinant enzymes | Homo sapiens | 3-(1-ethyl-3,4-dihydronaphthalen-2-yl)-pyridine | |
0.000045 | - |
CYP11B2 IC50: 45 nM, no inhibition of CYP11B1, recombinant enzymes | Homo sapiens | 3-(7-methoxy-3,4-dihydronaphthalen-2-yl)pyridine | |
0.000081 | - |
CYP11B2 IC50: 81 nM | Homo sapiens | ketoconazole | |
0.000176 | - |
CYP11B2 IC50: 176 nM, recombinant enzymes | Homo sapiens | 3-(4-ethyl-3,4-dihydronaphthalen-2-yl)pyridine | |
0.000224 | - |
IC50 CYP11B1 IC50: 224 nM, recombinant enzymes | Homo sapiens | ketoconazole | |
0.000288 | - |
CYP11B1 IC50: 288 nM | Homo sapiens | 3-[(Z)-2-phenylvinyl]pyridine | |
0.000334 | - |
CYP11B2 IC50: 334 nM, recombinant enzymes | Homo sapiens | 1-(3,4-dihydronaphthalen-2-yl)-1H-imidazole | |
0.000411 | - |
CYP11B2 IC50: 411 nM, recombinant enzymes | Homo sapiens | 1-(6-methoxy-3,4-dihydronaphthalen-2-yl)-1H-imidazole | |
0.000448 | - |
CYP11B2 IC50: 448 nM, no inhibition of CYP11B1, recombinant enzymes | Homo sapiens | 1-(1H-inden-2-yl)-1H-imidazole | |
0.000503 | - |
CYP11B1 IC50: 503 nM | Homo sapiens | 3-(3-methyl-3,4-dihydronaphthalen-2-yl)pyridine | |
0.000578 | - |
competitive, CYP11B1 IC50: 578 nM | Homo sapiens | 3-(6-methoxy-3,4-dihydronaphthalen-2-yl)pyridine | |
0.000639 | - |
CYP11B1 IC50: 639 nM | Homo sapiens | 1-(3,4-dihydronaphthalen-2-yl)-1H-imidazole | |
0.000735 | - |
CYP11B2 IC50: 735 nM, no inhibition by the 3-[(E)-2-phenylvinyl]pyridine isomer, recombinant enzymes | Homo sapiens | 3-[(Z)-2-phenylvinyl]pyridine | |
0.000763 | - |
CYP11B1 IC50: 763 nM | Homo sapiens | 1-(6-methoxy-3,4-dihydronaphthalen-2-yl)-1H-imidazole | |
0.001268 | - |
CYP11B1 IC50: 1268 nM | Homo sapiens | 3-(1-methyl-3,4-dihydronaphthalen-2-yl)-pyridine | |
0.001291 | - |
CYP11B1 IC50: 1291 nM | Homo sapiens | 3-(4-methyl-3,4-dihydronaphthalen-2-yl)pyridine | |
0.001615 | - |
CYP11B1 IC50: 1615 nM | Homo sapiens | 3-(4-ethyl-3,4-dihydronaphthalen-2-yl)pyridine | |
0.001729 | - |
CYP11B1 IC50: 1729 nM | Homo sapiens | 3-(3,4-dihydronaphthalen-2-yl)pyridine | |
0.002117 | - |
CYP11B1 IC50: 2117 nM | Homo sapiens | 3-(1-ethyl-3,4-dihydronaphthalen-2-yl)-pyridine | |
0.002529 | - |
CYP11B1 IC50: 2529 nM | Homo sapiens | 4-(6-methoxy-3,4-dihydronaphthalen-2-yl)pyridine | |
0.002834 | - |
CYP11B2 IC50: 2834 nM, recombinant enzymes | Homo sapiens | 4-(6-methoxy-3,4-dihydronaphthalen-2-yl)pyridine | |
0.005684 | - |
competitive, CYP11B1 IC50: 5684 nM | Homo sapiens | 3-(6-methoxy-1H-inden-2-yl)pyridine |