Literature summary for 1.14.18.3 extracted from

Itoyama, S.; Doitomi, K.; Kamachi, T.; Shiota, Y.; Yoshizawa, K.
Possible peroxo state of the dicopper site of particulate methane monooxygenase from combined quantum mechanics and molecular mechanics calculations (2016), Inorg. Chem., 55, 2771-2775 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	an integral membrane metalloenzyme	Methylococcus capsulatus	16020	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Cu2+	an integral membrane metalloenzyme, the enzyme has a dicopper active site, structures of the dicopper site of enzyme pMMO, overview. Possible peroxo state of the dicopper site of pMMO from combined quantum mechanics and molecular mechanics calculations. The pMMO active site is considered to contain two Cu ions with a Cu-Cu distance of about 2.58 A within the pmoB subunit. One copper is coordinated by two histidine imidazoles, and another is chelated by a histidine imidazole and primary amine of an N-terminal histidine. The QM region contains the two Cu ions, His33, His137, His139, Tyr374, and Glu35 for the resting state, and, in addition, two oxygen atoms for the peroxo state	Methylococcus capsulatus

Organism

Organism	UniProt	Comment	Textmining
Methylococcus capsulatus	G1UBD1 AND Q607G3	alpha- and beta-subunits	-
Methylococcus capsulatus Bath	G1UBD1 AND Q607G3	alpha- and beta-subunits	-

Subunits

Subunits	Comment	Organism
heterotrimer	the enzyme consists of three subunits, pmoB, pmoA, and pmoC, organized in an alpha3beta3gamma3 trimer	Methylococcus capsulatus

Synonyms

Synonyms	Comment	Organism
particulate methane monooxygenase	-	Methylococcus capsulatus
pMMO	-	Methylococcus capsulatus

General Information

General Information	Comment	Organism
additional information	the enzyme has a dicopper active site, analysis of the resting state and a possible peroxo state of the dicopper active site of pMMO by using combined quantum mechanics and molecular mechanics calculations on the basis of reported X-ray crystal structure, PDB ID 1YEW, of the resting state of pMMO. The pMMO active site is considered to contain two Cu ions with a Cu-Cu distance of about 2.58 A within the pmoB subunit. One copper is coordinated by two histidine imidazoles, and another is chelated by a histidine imidazole and primary amine of an N-terminal histidine. Possible Formation of a Peroxo Species in the Dicopper Site of pMMO, overview	Methylococcus capsulatus

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Release 2023.1 (January 2023)