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Literature summary for 1.14.20.13 extracted from

  • Schlesinger, D.; Davidovich Rikanati, R.; Volis, S.; Faigenboim, A.; Vendramin, V.; Cattonaro, F.; Hooper, M.; Oren, E.; Taylor, M.; Sitrit, Y.; Inbar, M.; Lewinsohn, E.
    Alkaloid chemodiversity in Mandragora spp. is associated with loss-of-functionality of MoH6H, a hyoscyamine 6beta-hydroxylase gene (2019), Plant Sci., 283, 301-310 .
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(6S)-6beta-hydroxyhyoscyamine + 2-oxoglutarate + O2 Mandragora officinarum
-
 scopolamine + succinate + CO2 + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Mandragora officinarum A0A6M6R352
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(6S)-6beta-hydroxyhyoscyamine + 2-oxoglutarate + O2
-
 Mandragora officinarum scopolamine + succinate + CO2 + H2O
-
 ?
(6S)-6beta-hydroxyhyoscyamine + 2-oxoglutarate + O2 the bifunctional enzyme also catalyzes the conversion of L-hyoscyamine to (6S)-hydroxyhyoscyamine, cf. 1.14.11.11 Mandragora officinarum scopolamine + succinate + CO2 + H2O
-
 ?

Synonyms

Synonyms Comment Organism
H6H
-
 Mandragora officinarum
hyoscyamine 6beta-hydroxylase
-
 Mandragora officinarum

General Information

General Information Comment Organism
physiological function the bifunctional enzyme catalyzes the last two steps in the scopolamine biosynthetic pathway: the hydroxylation of L-hyoscyamine to 6beta-hydroxyhyoscyamine (anisodamine) and its subsequent epoxidation to scopolamine Mandragora officinarum