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Literature summary for 1.14.99.58 extracted from

  • Furci, L.M.; Lopes, P.; Eakanunkul, S.; Zhong, S.; MacKerell, A.D.; Wilks, A.
    Inhibition of the bacterial heme oxygenases from Pseudomonas aeruginosa and Neisseria meningitidis: novel antimicrobial targets (2007), J. Med. Chem., 50, 3804-3813.
    View publication on PubMed
Search for more literature for 1.14.99.58

Application

Application Comment Organism
drug development the enzyme is a potential therapeutic target for antimicrobial drug development, computer-aided drug design and screening, overview Pseudomonas aeruginosa

Inhibitors

Inhibitors Comment Organism Structure
(2E)-2-[4-(dimethylamino)benzylidene]hydrazinecarboximidamide binding affinity 0.030 mM Pseudomonas aeruginosa
(2E)-2-[[4-(dimethylamino)phenyl]methylidene]hydrazinecarboximidamide binding affinity is 0.030 mM, complete inhibition Pseudomonas aeruginosa
(2Z)-4-[(4-anilinophenyl)amino]-4-oxobut-2-enoic acid binding affinity 0.0201 mM, above 0.25 mM significant decrease in growth of strain on heme as sole source of iron Pseudomonas aeruginosa
(2Z)-N'-[(1Z)-pyridin-3-ylmethylene]-2-(pyridin-3-ylmethylene)hydrazinecarboximidohydrazide binding affinity 0.0159 mM Pseudomonas aeruginosa
(2Z)-N'-[(1Z)-pyridin-3-ylmethylidene]-2-(pyridin-3-ylmethylidene)hydrazinecarboximidohydrazide binding affinity is 0.0159 mM, complete inhibition Pseudomonas aeruginosa
1-(2,4-dinitrophenyl)methanamine binding affinity 0.187 mM Pseudomonas aeruginosa
2-(4-chlorophenyl)-N'-[(1E)-1H-indol-3-ylmethylidene]acetohydrazide binding affinity is 0.0158 mM, complete inhibition Pseudomonas aeruginosa
2-(4-chlorophenyl)-N'-[(1Z)-1H-inden-3-ylmethylene]acetohydrazide binding affinity 0.0158 mM, above 0.25 mM significant decrease in growth of strain on heme as sole source of iron Pseudomonas aeruginosa
4-oxo-4-[[4-(phenylamino)phenyl]amino]butanoic acid binding affinity is 0.0201 mM, complete inhibition Pseudomonas aeruginosa
4-[(2-hydroxyphenyl)amino]naphthalene-1,2-dione binding affinity is 0.0728 mM, partial inhibition Pseudomonas aeruginosa
N'-(pyridin-4-ylcarbonyl)pyridine-4-carbohydrazide binding affinity is 0.0447 mM, partial inhibition Pseudomonas aeruginosa
N-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-2-nitrobenzamide binding affinity is 0.0061 mM, complete inhibition Pseudomonas aeruginosa
N-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-3-nitrobenzamide binding affinity 0.0061 mM Pseudomonas aeruginosa

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ essential requirement Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
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