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Literature summary for 1.14.99.66 extracted from

  • Tsai, W.W.; Nguyen, T.T.; Shi, Y.; Barton, M.C.
    p53-targeted LSD1 functions in repression of chromatin structure and transcription in vivo (2008), Mol. Cell. Biol., 28, 5139-5146.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.99.66

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of Flag-tagged p53 or LSD1 in U2OS cells Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information overexpression of Flag-tagged p53 or LSD1 in U2OS cells, which express endogenous p53, does not cause a generalized decrease in cellular H3K4me2 levels Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information in p53-null mice, LSD1 binding is depleted, H3K4me2 is increased, and H3K9me2 remains unchanged compared to those of the wild type Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus p53 directly interacts with LSD1 to alter chromatin structure and confer developmental repression of the tumor marker alpha-fetoprotein, AFP, p53 and LSD1 cooccupy a p53 response element, concomitant with dimethylated histone H3 lysine 4 demethylation and postnatal repression of AFP transcription, overview ?
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2 Mus musculus
-
 [histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information p53 directly interacts with LSD1 to alter chromatin structure and confer developmental repression of the tumor marker alpha-fetoprotein, AFP, p53 and LSD1 cooccupy a p53 response element, concomitant with dimethylated histone H3 lysine 4 demethylation and postnatal repression of AFP transcription, overview Mus musculus ?
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2
-
 Mus musculus [histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?

Synonyms

Synonyms Comment Organism
LSD1
-
 Mus musculus
lysine-specific demethylase 1
-
 Mus musculus

General Information

General Information Comment Organism
malfunction in p53-null mice, LSD1 binding is depleted, H3K4me2 is increased, and H3K9me2 remains unchanged compared to those of the wild type. Partial hepatectomy of wild-type mouse liver and induces a regenerative response, which leads to a loss of p53, increases H3K4me2, and decreases LSD1 interaction at AFP chromatin, in parallel with reactivation of AFP expression Mus musculus
physiological function LSD1 is targeted to chromatin by p53, likely in a gene-specific manner, and define a molecular mechanism by which p53 mediates transcription repression in vivo during differentiation Mus musculus