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Literature summary for 1.2.1.36 extracted from

  • Park, J.W.; Jung, K.H.; Lee, J.H.; Moon, S.H.; Cho, Y.S.; Lee, K.H.
    Inhibition of aldehyde dehydrogenase 1 enhances the cytotoxic effect of retinaldehyde on A549 cancer cells (2017), Oncotarget, 8, 99382-99393 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.1.36

Inhibitors

Inhibitors Comment Organism Structure
N,N-diethylaminobenzaldehyde
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
retinal + NAD+ + H2O Homo sapiens
-
 retinoate + NADH + 2 H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
H-1666 cell
-
 Homo sapiens
-
lung cancer cell
-
 Homo sapiens
-
NCI-H522 cell
-
 Homo sapiens
-
T-47D cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
BODIPY-aminoacetaldehyde + NAD+ + H2O
-
 Homo sapiens ?
-
 ?
retinal + NAD+ + H2O
-
 Homo sapiens retinoate + NADH + 2 H+
-
 ?

Synonyms

Synonyms Comment Organism
aldehyde dehydrogenase 1
-
 Homo sapiens
ALDH1A1
-
 Homo sapiens
Aldh1a3
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function ALDH1A1 contributes to protection of A-549 cells against retinaldehyde toxicity. ALDH1 confers protection against retinaldehyde toxicity in cancer cells Homo sapiens