Literature summary for 1.2.1.75 extracted from

Lama, S.; Kim, Y.; Nguyen, D.T.; Im, C.H.; Sankaranarayanan, M.; Park, S.
Production of 3-hydroxypropionic acid from acetate using metabolically-engineered and glucose-grown Escherichia coli (2021), Biores. Technol., 320, 124362 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21(DE3) cells	Chloroflexus aurantiacus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
malonate semialdehyde + NADPH + H+	Chloroflexus aurantiacus	-	3-hydroxypropionic acid + NADP+	-	?
malonyl-CoA + NADPH + H+	Chloroflexus aurantiacus	-	malonate semialdehyde + CoA + NADP+	-	?

Organism

Organism	UniProt	Comment	Textmining
Chloroflexus aurantiacus	Q6QQP7	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
malonate semialdehyde + NADPH + H+	-	Chloroflexus aurantiacus	3-hydroxypropionic acid + NADP+	-	?
malonyl-CoA + NADPH + H+	-	Chloroflexus aurantiacus	malonate semialdehyde + CoA + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
malonyl-CoA reductase	-	Chloroflexus aurantiacus
MCR	-	Chloroflexus aurantiacus

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	dependent on	Chloroflexus aurantiacus

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Release 2023.1 (January 2023)