Literature summary for 1.2.3.1 extracted from

Ogiso, T.; Fukami, T.; Mishiro, K.; Konishi, K.; Jones, J.P.; Nakajima, M.
Substrate selectivity of human aldehyde oxidase 1 in reduction of nitroaromatic drugs (2018), Arch. Biochem. Biophys., 659, 85-92 .

Search for more literature for 1.2.3.1

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0067	-	clonazepam	liver cytosol, pH 7.4, 37°C	Homo sapiens
0.0185	-	nimetazepam	liver cytosol, pH 7.4, 37°C	Homo sapiens
0.0383	-	nilutamide	liver cytosol, pH 7.4, 37°C	Homo sapiens
0.046	-	flunitrazepam	liver cytosol, pH 7.4, 37°C	Homo sapiens
0.053	-	flutamide	liver cytosol, pH 7.4, 37°C	Homo sapiens
0.2014	-	nimesulide	liver cytosol, pH 7.4, 37°C	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Homo sapiens	5829	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q06278	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
azelnidipine + H2O + O2	-	Homo sapiens	? + H2O2	-	?
clonazepam + H2O + O2	-	Homo sapiens	? + H2O2	-	?
flunitrazepam + H2O + O2	-	Homo sapiens	? + H2O2	-	?
flutamide + H2O + O2	-	Homo sapiens	? + H2O2	-	?
nifedipine + H2O + O2	-	Homo sapiens	? + H2O2	-	?
nilutamide + H2O + O2	-	Homo sapiens	? + H2O2	-	?
nimesulide + H2O + O2	-	Homo sapiens	? + H2O2	-	?
nimetazepam + H2O + O2	-	Homo sapiens	? + H2O2	-	?
nimodipine + H2O + O2	-	Homo sapiens	? + H2O2	-	?

General Information

General Information	Comment	Organism
metabolism	nitroaromatic drugs clonazepam, flunitrazepam, flutamide, nilutamide, nimesulide, and nimetazepam are substantially reduced by recombinant AOX1 and human liver cytosol, whereas azelnidipine, nifedipine, and nimodipine are slightly reduced and metronidazole and tolcapone are not reduced. Nitroaromatic drugs reduced by AOX1 possess a relatively electron-deficient nitro group	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)