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Literature summary for extracted from

  • Baettig, P.; Muehlemann, K.
    Influence of the spxB gene on competence in Streptococcus pneumoniae (2008), J. Bacteriol., 190, 1184-1189.
    View publication on PubMedView publication on EuropePMC


Application Comment Organism
additional information pneumococcal spxB gene influences competence, the mechanism remains elusive Streptococcus pneumoniae D39


Cloned (Comment) Organism
expressed in Escherichia coli Streptococcus pneumoniae D39

Protein Variants

Protein Variants Comment Organism
additional information knockout of the spxB gene in strain D39 abolishes spontaneous transformation. Significant reduced expression levels of comC and recA as well as DNA release from bacterial cells during the early growth phase, coincident with the time of spontaneous competence in the parent strain. Supplementation with competencestimulating peptide 1 restores transformation. Neither supplementation with competencestimulating peptide 1 nor supplementation with the SpxB products H2O2 and acetate alteres DNA release. Supplementation of the parent strain with catalase does not reduce DNA release significantly Streptococcus pneumoniae D39


Organism UniProt Comment Textmining
Streptococcus pneumoniae D39
serotype 2


Synonyms Comment Organism
Streptococcus pneumoniae D39