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Literature summary for 1.2.4.1 extracted from

  • Grabowska, E.; Czerniecka, M.; Czyzewska, U.; Zambrzycka, A.; Lotowski, Z.; Tylicki, A.
    Differences in the efficiency of 3-deazathiamine and oxythiamine pyrophosphates as inhibitors of pyruvate dehydrogenase complex and growth of HeLa cells in vitro (2021), J. Enzyme Inhib. Med. Chem., 36, 122-129 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.4.1

Inhibitors

Inhibitors Comment Organism Structure
3-deazathiamine diphosphate competitive inhibitor, compound added to the culture medium for HeLa cells does not hamper the rate of cell growth and shows not significant impact on the viability of the cells Homo sapiens
3-deazathiamine diphosphate competitive inhibitor Sus scrofa
Oxythiamine diphosphate competitive inhibitor, shows a significant cytostatic effect on HeLa cell culture Homo sapiens
Oxythiamine diphosphate competitive inhibitor Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Sus scrofa 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000026
-
 pH 7.8, temperature not specified in the publication Sus scrofa 3-deazathiamine diphosphate
0.000025
-
 pH 7.8, temperature not specified in the publication Sus scrofa Oxythiamine diphosphate