Literature summary for 1.2.4.4 extracted from

Knapik-Czajka, M.; Jurczyk, M.; Bielen, J.; Aleksandrovych, V.; Gawedzka, A.; Stach, P.; Drag, J.; Gil, K.
Effect of 5-fluorouracil on branched-chain alpha-keto acid dehydrogenase (BCKDH) complex in rats heart (2021), Folia Med. Crac., 61, 121-129 .

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Activating Compound

Activating Compound	Comment	Organism	Structure
5-fluorouracil	in male rats administered with 4 doses of 5-FU, 150 mg/kg b.wt. each, 5-FU treatment causes an increase in branched-chain alpha-keto acid dehydrogenase complex BCKDH activity that results mainly from increased dephosphorylation of the complex and is associated with an increase of phosphatase PPM1K mRNA level and reduction of BDK and dehydrogenase E1 mRNA levels	Rattus norvegicus

Application

Application	Comment	Organism
medicine	in male rats administered with 4 doses of 5-FU, 150 mg/kg b.wt. each, 5-FU treatment causes an increase in branched-chain alpha-keto acid dehydrogenase complex BCKDH activity that results mainly from increased dephosphorylation of the complex and is associated with an increase of phosphatase PPM1K mRNA level and reduction of BDK and dehydrogenase E1 mRNA levels	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Rattus norvegicus	5739	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P11960 and P35738	P11960 i.e. E1 subunit alpha, P35738 i.e. E1 subunit beta	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	-	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
BCKDHA	-	Rattus norvegicus
BCKDHB	-	Rattus norvegicus

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Release 2023.1 (January 2023)