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Literature summary for extracted from

  • Mohsen, A.W.; Rigby, S.E.; Jensen, K.F.; Munro, A.W.; Scrutton, N.S.
    Thermodynamic basis of electron transfer in dihydroorotate dehydrogenase B from Lactococcus lactis: analysis by potentiometry, EPR spectroscopy, and ENDOR spectroscopy (2004), Biochemistry, 43, 6498-6510.
    View publication on PubMed


Organism UniProt Comment Textmining
Lactococcus lactis


Reaction Comment Organism Reaction ID
(S)-dihydroorotate + NAD+ = orotate + NADH + H+ detailed thermodynamic analysis, midpoint reduction potential of 2Fe-2S center -212 mV, midpoint reduction potential of FMN -298 mV Lactococcus lactis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dihydroorotate + NAD+
Lactococcus lactis orotate + NADH + H+


Cofactor Comment Organism Structure
Lactococcus lactis
Lactococcus lactis
iron-sulfur centre 2FE-2S cluster Lactococcus lactis