Inhibitors | Comment | Organism | Structure |
---|---|---|---|
17beta-estradiol | - |
Mus musculus | |
5alpha-Androstan-3-beta-ol-17-one | - |
Mus musculus | |
5alpha-Pregnan-3beta-21-one | - |
Mus musculus | |
5beta-androstan-3beta-ol-17-one | - |
Mus musculus | |
5beta-Pregnan-3beta-ol-20-one | - |
Mus musculus | |
Dienstrol | - |
Mus musculus | |
Hexestrol | - |
Mus musculus | |
Stilbestrol | - |
Mus musculus | |
testosterone | - |
Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Mus musculus | |
0.67 | - |
cis-benzene dihydrodiol | NAD+, DD1 | Mus musculus | |
0.77 | - |
trans-benzene dihydrodiol | NADP+, DD1 | Mus musculus | |
0.91 | - |
cis-benzene dihydrodiol | NAD+ | Mus musculus | |
1.28 | - |
cis-benzene dihydrodiol | NADP+, DD3 | Mus musculus | |
1.99 | - |
cis-benzene dihydrodiol | trans-benzene dihydrodiol, NADP+, DD1 | Mus musculus | |
6.78 | - |
Naphthalene dihydrodiol | NADP+ | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Mus musculus | 5737 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
39000 | - |
1 * 39000, kidney, SDS-PAGE | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | metabolic inactivation of dihydrodiols or dihydrodiol epoxides derived from carcinogenic polycylic hydrocarbons | ? | - |
? | |
naphthalene dihydrodiol + NAD(P)+ | Mus musculus | - |
? | - |
? | |
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+ | Mus musculus | - |
catechol + NAD(P)H | - |
? | |
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+ | Mus musculus | - |
catechol + NAD(P)H | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
dihydrodiol dehydrogenase EC 1.3.1.20 and 3(17)alpha-hydroxysteroid dehydrogenase EC 1.1.1.59 activities reside on a single protein | - |
Mus musculus | - |
enzyme forms: DD1, DD3 | - |
Purification (Comment) | Organism |
---|---|
dihydrodiol dehydrogenase EC 1.3.1.20 and 3(17)alpha-hydroxysteroid dehydrogenase EC 1.1.1.59 activities reside on a single protein | Mus musculus |
enzyme forms: DD1, DD3 | Mus musculus |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH + H+ | isoform DD3 probably identical with 3(17)alpha-hydroxysteroid dehydrogenase EC 1.1.1.59 and D-xylose dehydrogenase EC 1.1.1.179 | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | low activity | Mus musculus | - |
heart | low activity | Mus musculus | - |
kidney | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
lung | low activity | Mus musculus | - |
testis | low activity | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
17beta-estradiol + NAD(P)+ | isoform DD3: dihydrodiol dehydrogenase EC 1.3.1.20 and 3(17)alpha-hydroxysteroid dehydrogenase EC 1.1.1.59 activities reside on a single protein | Mus musculus | ? | - |
? | |
3-keto steroid + NAD(P)H | probably reversible reaction | Mus musculus | 3alpha-hydroxy steroid + NAD(P)+ | - |
? | |
3alpha-hydroxy steroid + NADP+ | - |
Mus musculus | 3-keto steroid + NADPH | - |
? | |
4-nitrobenzaldehyde + NAD(P)H | - |
Mus musculus | 4-nitrobenzylalcohol + NAD(P)+ | - |
? | |
alicyclic alcohol + NAD(P)+ | - |
Mus musculus | ? | - |
? | |
camphorquinone + NAD(P)H | - |
Mus musculus | (1R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+ | - |
? | |
cis-1,2-dihydrobenzene-1,2-diol + NAD(P)+ | - |
Mus musculus | catechol + NAD(P)H | - |
r | |
epitestosterone + NAD(P)+ | isoform DD3: dihydrodiol dehydrogenase EC 1.3.1.20 and 3(17)alpha-hydroxysteroid dehydrogenase EC 1.1.1.59 activities reside on a single protein | Mus musculus | ? | - |
? | |
glycolithocholic acid + NAD(P)+ | NAD+ preferred as cofactor | Mus musculus | 3-oxo-glycocholanoic acid + NAD(P)H | - |
? | |
additional information | metabolic inactivation of dihydrodiols or dihydrodiol epoxides derived from carcinogenic polycylic hydrocarbons | Mus musculus | ? | - |
? | |
additional information | NADP+ or NAD+ as cofactors | Mus musculus | additional information | - |
? | |
naphthalene dihydrodiol + NAD(P)+ | - |
Mus musculus | ? | - |
? | |
tetrahydrodeoxycorticosterone + NAD(P)+ | isoform DD3: dihydrodiol dehydrogenase EC 1.3.1.20 and 3(17)alpha-hydroxysteroid dehydrogenase EC 1.1.1.59 activities reside on a single protein | Mus musculus | ? | - |
? | |
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+ | - |
Mus musculus | catechol + NAD(P)H | - |
? | |
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+ | - |
Mus musculus | catechol + NAD(P)H | - |
r | |
trans-naphthalene dihydrodiol + NAD(P)+ | - |
Mus musculus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 39000, kidney, SDS-PAGE | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
DD | - |
Mus musculus |
dihydrodiol dehydrogenase | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Mus musculus |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
45 | - |
dihydrodiol dehydrogenase and 3(17)alpha-hydroxysteroid dehydrogenase activity, pH 7.5, 5 min | Mus musculus |
50 | - |
dihydrodiol dehydrogenase and 3(17)alpha-hydroxysteroid dehydrogenase activity, pH 7.5, all activity lost | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Mus musculus | |
NADH | - |
Mus musculus | |
NADP+ | - |
Mus musculus |