Inhibitors | Comment | Organism | Structure |
---|---|---|---|
17alpha-hydroxyprogesterone | - |
Rattus norvegicus | |
androst-4-enedione | - |
Rattus norvegicus | |
NADP+ | - |
Rattus norvegicus | |
progesterone | competitive | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0002 | - |
testosterone | nuclear and microsomal solubilized enzyme | Rattus norvegicus | |
0.00102 | - |
NADPH | nuclear enzyme | Rattus norvegicus | |
0.0376 | - |
NADPH | microsomal membrane-bound enzyme | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
nucleus | - |
Rattus norvegicus | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epididymis | - |
Rattus norvegicus | - |
Storage Stability | Organism |
---|---|
-20°C, 1 week, solubilized enzyme | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholest-4-en-3-one + NADPH | - |
Rattus norvegicus | 5-alpha-cholestan-3-one + NADP+ | - |
? | |
testosterone + NADPH + H+ | - |
Rattus norvegicus | 17beta-hydroxy-5alpha-androstan-3-one + NADP+ | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.8 | 7.5 | - |
Rattus norvegicus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5 | 8.5 | at pH 5 and 8.5: about 50% of activity maximum | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Rattus norvegicus |