Cloned (Comment) | Organism |
---|---|
reversible overexpression of BVR in mouse fibroblasts, doxycycline-dependent overexpression of BVR in NIH 3T3 BVR-Tet-On cells confers protection against cytotoxic drugs cisplatin and doxorubicin | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
bilirubin + NAD+ | Homo sapiens | - |
biliverdin + NADH + H+ | - |
r | |
bilirubin + NADP+ | Homo sapiens | - |
biliverdin + NADPH + H+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P53004 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HaCaT cell | - |
Homo sapiens | - |
keratinocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
bilirubin + NAD+ | - |
Homo sapiens | biliverdin + NADH + H+ | - |
r | |
bilirubin + NADP+ | - |
Homo sapiens | biliverdin + NADPH + H+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
biliverdin reductase A | - |
Homo sapiens |
BVR | - |
Homo sapiens |
BVRA | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.7 | - |
with cofactor NADH | Homo sapiens |
8.7 | - |
with cofactor NADPH | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens | |
NADH | - |
Homo sapiens | |
NADP+ | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | doxycycline dose-dependently induces BVR gene expression at the level of mRNA as well as a protein, and BVR activity in genetically modified NIH 3T3 fibroblasts | up |
General Information | Comment | Organism |
---|---|---|
additional information | the BVR activity and expression is not affected by MAP kinase inhibitors, overview | Homo sapiens |
physiological function | biliverdin reductase converts biliverdin to bilirubin. Additionally, acting as a transcription factor and possessing a capacity of a serine/threonine kinase, it may modulate signaling pathways. BVR exhibits cytoprotection, important role of PKCa/b kinase in BVR-mediated improvement in cell survival | Homo sapiens |