Application | Comment | Organism |
---|---|---|
medicine | therapeutic potential of human BVR and human HVR-based peptides by affecting the MAPK signaling pathways, overview | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
R18Stop | a naturally occuring mutation of BVR leading to a severely truncated enzyme, liver cirrhosis and death | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
bilirubin-IXa + NAD+ | Homo sapiens | - |
biliverdin-IXa + NADH + H+ | - |
? | |
bilirubin-IXa + NADP+ | Homo sapiens | - |
biliverdin-IXa + NADPH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
renal carcinoma cell | shows increased BVR level | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
bilirubin-IXa + NAD+ | - |
Homo sapiens | biliverdin-IXa + NADH + H+ | - |
? | |
bilirubin-IXa + NADP+ | - |
Homo sapiens | biliverdin-IXa + NADPH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BVR | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens | |
NADH | - |
Homo sapiens | |
NADP+ | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | in HEK-293A cells, hypoxia modestly increases BVR mRNA levels | up |
General Information | Comment | Organism |
---|---|---|
additional information | bilirubin is an important component of cellular defense mechanisms with cytoprotective features | Homo sapiens |
physiological function | BVR is required for heme degradation. BVR plays a role in bile pigment metabolism, in cell protection, and in signal transduction, detailed overview. BVR reverses the inhibitory effect of biliverdin on PKC enzymes | Homo sapiens |