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Literature summary for 1.3.1.9 extracted from
- Structural basis for inhibition of enoyl-[acyl carrier protein] reductase (InhA) from Mycobacterium tuberculosis (2020), Curr. Med. Chem., 27, 745-759 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| isoniazid | potent inhibitor | Mycobacterium tuberculosis |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| trans-DELTA2-enoyl-[acyl-carrier protein] + NADH + H+ | Mycobacterium tuberculosis | - |
enoyl-[acyl-carrier protein] + NAD+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | P9WGR1 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| trans-DELTA2-enoyl-[acyl-carrier protein] + NADH + H+ | - |
Mycobacterium tuberculosis | enoyl-[acyl-carrier protein] + NAD+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| InhA | - |
Mycobacterium tuberculosis |
| trans-enoyl-[acyl carrier protein] reductase | - |
Mycobacterium tuberculosis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | - |
Mycobacterium tuberculosis | |
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Release 2023.1 (January 2023)
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