Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.3.3.6 extracted from

  • Shi, H.; Huang, X.; Chen, X.; Yang, Y.; Wang, Z.; Yang, Y.; Wu, F.; Zhou, J.; Yao, C.; Ma, G.; Du, A.
    Acyl-CoA oxidase ACOX-1 interacts with a peroxin PEX-5 to play roles in larval development of Haemonchus contortus (2021), PLoS Pathog., 17, e1009767 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.3.6

Cloned(Commentary)

Cloned (Comment) Organism
expressed in in HEK293T cells and Saccharomyces cerevisiae Haemonchus contortus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00683
-
 palmitoyl-CoA isoform isoform ACOX-1.2, at pH 7.5 and 42°C Haemonchus contortus
0.01264
-
 palmitoyl-CoA isoform isoform ACOX-1.3, at pH 7.5 and 42°C Haemonchus contortus
0.07879
-
 palmitoyl-CoA isoform isoform ACOX-1.1, at pH 7.5 and 37°C Haemonchus contortus

Organism

Organism UniProt Comment Textmining
Haemonchus contortus
-
-
-
Haemonchus contortus ZJ
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hypodermis the enzyme is predominantly expressed in the hypodermis of Haemonchus contortus, particularly in the early larval stages in the environment and the arrested fourth larval stage within host animals Haemonchus contortus
-
intestine the enzyme is predominantly expressed in the intestine of Haemonchus contortus, particularly in the early larval stages in the environment and the arrested fourth larval stage within host animals Haemonchus contortus
-
larva
-
 Haemonchus contortus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information ACOX-1 interacts with PEX-5 in peroxisomes Haemonchus contortus ?
-
-
additional information ACOX-1 interacts with PEX-5 in peroxisomes Haemonchus contortus ZJ ?
-
-
palmitoyl-CoA + O2
-
 Haemonchus contortus trans-2,3-dehydropalmitoyl-CoA + H2O2
-
 ?
palmitoyl-CoA + O2
-
 Haemonchus contortus ZJ trans-2,3-dehydropalmitoyl-CoA + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
ACOX-1.1 isoform Haemonchus contortus
ACOX-1.2 isoform Haemonchus contortus
ACOX-1.3 isoform Haemonchus contortus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 isoform ACOX-1.1 Haemonchus contortus
42
-
 isoforms ACOX-1.2 and ACOX-1.3 Haemonchus contortus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
 Haemonchus contortus

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Haemonchus contortus

Expression

Organism Comment Expression
Haemonchus contortus isoform Acox-1.1 is highly transcribed in the egg and diapause stages, particularly in the latter. Isoform Acox-1.2 is predominantly transcribed in the egg, L1, L2 and L3 stages collected from the environment while transcribed at low level in the diapause stage collected from the host animals. Isoform Acox-1.3 is highly transcribed in the early developmental stages up

General Information

General Information Comment Organism
malfunction enzyme knockdown results in a lethal phenotype of the infective stage and likely developmental parasitic larval stage within host animals Haemonchus contortus
physiological function the enzyme plays an essential role in the post-embryonic larval development Haemonchus contortus